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Central Functions of the Ghrelin Receptor

  • Book
  • © 2014

Overview

Editors:
  1. Jeanelle Portelli

    1. Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium

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    You can also search for this editor in PubMed   Google Scholar

  2. Ilse Smolders

    1. Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • The first book to present a comprehensive overview of the ghrelin receptor
  • Describes the role of ghrelin in feeding and adictive behavior, memory, sleep, and arousal
  • Explores options for bringing selected high potential GHSR ligands to a clinical setting

Part of the book series: The Receptors (REC, volume 25)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xvii
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  2. The ghrelin receptor isoforms

    1. Front Matter

      Pages 1-1
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    2. Constitutive Activity of the Ghrelin Receptor

      • Jacek MokrosiÅ„ski, Andreas Nygaard Madsen, Birgitte Holst
      Pages 3-19

    3. Homodimerization and Heterodimerization of the Ghrelin Receptor

      • Alessandro Laviano, Alessia Mari
      Pages 21-31

  3. Mechanisms of Ghrelin’s Action

    1. Front Matter

      Pages 33-33
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    2. The Role of the Ghrelin Receptor in Appetite and Energy Metabolism

      • Romana Stark, Zane B. Andrews
      Pages 35-52

    3. The Vagus Nerve and Ghrelin Function

      • Yukari Date
      Pages 53-61

  4. Ghrelin Receptors in Food and Drug Addictive Mechanisms

    1. Front Matter

      Pages 63-63
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    2. Central Ghrelin Receptors and Food Intake

      • Mario Perello, Jesica Raingo
      Pages 65-88

    3. The Ghrelin Receptor: A Novel Therapeutic Target for Obesity

      • Harriët Schellekens, Timothy G. Dinan, John F. Cryan
      Pages 89-122

    4. Ghrelin Receptor Antagonism as a Potential Therapeutic Target for Alcohol Use Disorders: A Preclinical Perspective

      • Elisabet Jerlhag, Jörgen A. Engel
      Pages 123-134

    5. Clinical Research on the Ghrelin Axis and Alcohol Consumption

      • Allison A. Feduccia, Lorenzo Leggio
      Pages 135-149

  5. Ghrelin Plays a Role in Various Physiological and Pathophysiological Brain Functions

    1. Front Matter

      Pages 151-151
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    2. Ghrelin and Sleep Regulation

      • Éva Szentirmai, Levente Kapás
      Pages 153-165

    3. Ghrelin and Memory

      • Nicolas Kunath, Martin Dresler
      Pages 167-175

    4. Ghrelin Receptors and Epilepsy

      • Jeanelle Portelli, Ann Massie, Jessica Coppens, Ilse Smolders
      Pages 177-189

    5. Ghrelin Plays a Role in Various Physiological and Pathophysiological Brain Functions

      • Sarah J. Spencer
      Pages 191-204

    6. Ghrelin and Parkinson’s Disease

      • Marcus M. Unger, Wolfgang H. Oertel
      Pages 205-211

  6. Back Matter

    Pages 213-214
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Keywords

About this book

The Ghrelin receptor was identified before its natural ligand ghrelin. This receptor is found both centrally and peripherally, and has been shown to affect various processes, such as food intake, gut motility, memory, glucose and lipid metabolism, cardiovascular performances, reproduction, memory, and immunological responses, amongst others. The functions of the ghrelin receptor in the central nervous system are numerous and are still being explored. In this book we specifically focus on the various roles of the ghrelin receptor in the central nervous system. In a first set of chapters, the book will focus on the discovery and the properties of this intriguing constitutively active G-protein coupled receptor, on its multiple intracellular transduction mechanisms and the various subtypes of the currently known ghrelin receptor complexes. Next, the book will elaborate on the mitochondrial mechanisms regulated by the ghrelin receptor, its role in feeding and drug addictive mechanisms, memory, sleep and arousal. The final chapters focus on the potential of this receptor as a target for the treatment of neurological disorders including Parkinson’s disease, epilepsy, anxiety and depression.

Editors and Affiliations

  • Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium

    Jeanelle Portelli, Ilse Smolders

Bibliographic Information

  • Book Title: Central Functions of the Ghrelin Receptor

  • Editors: Jeanelle Portelli, Ilse Smolders

  • Series Title: The Receptors

  • DOI: https://doi.org/10.1007/978-1-4939-0823-3

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media New York 2014

  • Hardcover ISBN: 978-1-4939-0822-6Published: 16 May 2014

  • Softcover ISBN: 978-1-4939-5534-3Published: 03 September 2016

  • eBook ISBN: 978-1-4939-0823-3Published: 15 May 2014

  • Series ISSN: 1048-6909

  • Series E-ISSN: 2524-6488

  • Edition Number: 1

  • Number of Pages: XVII, 214

  • Number of Illustrations: 5 b/w illustrations, 7 illustrations in colour

  • Topics: Neurosciences, Neurochemistry

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