Lecithin

1. Front Matter

   Pages i-x

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2. Technology

   1. Overview on Phospholipids: Chemistry, Nomenclature and Analytical Methodology

      • G. B. Ansell

      Pages 1-1

   2. Modern Techniques for the Fractionation and Purification of Phospholipids from Biological Materials

      • Lloyd A. Horrocks, Laura L. Dugan, Cheryl J. Flynn, Gianfrancesco Goracci, Serena Porcellati, Young Yeo

      Pages 3-16

   3. Microorganisms as Sources of Phospholipids

      • Colin Ratledge

      Pages 17-35

   4. Partial Synthesis of Glycerophospholipids

      • A. Hermetter, F. Paltauf

      Pages 37-45

   5. Drug Entrapment by Phospholipids

      • Rolf E. Schubert, Karl-Heinz Schmidt

      Pages 47-59

3. Biology

   1. Absorption and Distribution of Phospholipids

      • Björn Åkesson, Åke Nilsson

      Pages 61-72

   2. Control of Lecithin Metabolism

      • Dennis E. Vance

      Pages 73-83

   3. Phospholipids in Cellular Survival and Growth

      • J. K. Blusztajn, U. I. Richardson, M. Liscovitch, C. Mauron, Richard J. Wurtman

      Pages 85-94

   4. Nutritional Considerations of Lecithin Administration

      • W. Feldheim

      Pages 95-99

   5. Use of Soybean Lecithin in Parenteral Nutrition

      • Guy Dutot

      Pages 101-106

4. Therapeutic Considerations

   1. Phosphatidylcholine: Endogenous Precursor of Choline

      • Steven H. Zeisel

      Pages 107-120

   2. Use of Phosphatidylcholine in Brain Diseases: An Overview

      • John H. Growdon

      Pages 121-136

   3. The Therapeutic Value of Phosphatidylserine Effect in the Aging Brain

      • Gino Toffano

      Pages 137-146

   4. Effects of Lecithin on Memory and Learning

      • Hardo Sorgatz

      Pages 147-153

   5. Dissemination and Activity of AL 721 after Oral Administration

      • Meir Shinitzky, Rachel Haimovitz

      Pages 155-166

   6. Effect of Dietary Lecithin and Nature of Dietary Fat Upon Growth and Bile Composition in the Gerbil

      • Tom R. Watkins, Anthony Pagano

      Pages 167-178

5. Panel Discussions

   1. Panel Discussions

      • Michael Schneider, Israel Hanin, G. Pepeu, G. Brian Ansell

      Pages 179-185

6. Back Matter

   Pages 186-196

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Recently, there has been tremendous scientific interest in the role of phospholipids and particularly phosphatidylcholine (lecithin) in a variety of biological processes. These include the involvement of phosphatidylcholine in biological membranes, as a component of plasma lipoprotein, as a transporter of choline in the body, and also as a "reserve", and possibly only source of unesterified choline. Moreover, numerous clinical studies have recently been conducted, to evaluate the possible uses of externally supplied lecithin in the treatment of some intractible neuropsychiatric disorders (e.g. tardive dyski.nesia, Alzheimer's disease, etc.) and other conditions (e.g. hypercholesteremia). Results to date are encouraging, yet equivocal. This is due, in part, to the fact that the field of phospholipid methodology is highly complex. There is much confusion in the literature, and many ambiguities still remain in the interpretation of experimental findings. This is particularly so for phenomena involving phospholipid function in the central nervous system. This book incorporates the proceedings of the Fourth International Colloquium on Lecithin, which took place in Chicago, Illinois, USA, on September 15-17, 1986. The purpese of this colloquium was to review, in a comprehensive manner, basic principles as weli as current information about the technology, biochemistry, physiology and therapeutic potential of lecithin. Over 108 individuals from all over the world participated in the sessions. The meeting was subdivided into oral presentations and panel discussions (see Table of Contents). It was sponsored and financed by the Lucas Meyer GmbH (Hamburg), for which the editors are most grateful.

• Alzheimer's disease
• Alzheimer´s disease
• biochemistry
• nervous system
• physiology

• Loyola University Stritch School of Medicine, Chicago, USA

  Israel Hanin

• Medical School, University of Birmingham, Birmingham, UK

  G. Brian Ansell

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