Department of Biological Chemistry School of Medicine and the Brain Research Institute, University of California Center for the Health Sciences, Los Angeles, USA
Volume V deals with the problems of turnover in the nervous system. "Turnover" is defined in different ways, and the term is used in different contexts. It is used rather broadly in the present volume, and intentionally so. The turnover of macromolecules is only one aspect; here "turnover" in dicates the simultaneous and coordinated formation and breakdown of macromolecular species. The complexities of cerebral protein turnover are shown in a separate chapter dealing with the synthesis of proteins, in another on breakdown, and in still another on the relationship of these two (showing how the two halves of turnover are controlled). The fact that most likely the two halves of protein turnover, synthesis and breakdown, are separated spatially and the mechanisms involved are different further emphasizes the complexity of macromolecular turnover. "Turnover" is used in a different context when the turnover of a cycle is discussed; but here again a number of complex metabolic reactions have to be interrelated and controlled; some such cycles are discussed briefly in this volume, additional cycles have been discussed with metabolism, and some cycles still await elucidation or discovery.
Authors and Affiliations
Department of Biological Chemistry School of Medicine and the Brain Research Institute, University of California Center for the Health Sciences, Los Angeles, USA
Sidney Roberts
Department of Pharmacology, Yale University School of Medicine, New Haven, USA
P. Greengard,
J. M. Ritchie
The Division of Neurochemistry Department of Neurology, The Mount Sinai School of Medicine, New York, USA
Michael M. Brand,
G. M. Lehrer
Departments of Anatomy and Surgery College of Physicians and Surgeons, Columbia University, New York, USA
Margaret R. Murray
New York State Research Institute for Neurochemistry and Drug Addiction, USA
N. Marks,
A. Lajtha,
Sze-Chuh Cheng
Department of Biochemistry Institute of Psychiatry, British Postgraduate Medical Federation University of London, London, England
R. Rodnight
Centre de Neurochimie du, Centre National de la Recherche Scientifique, Strasbourg, France
Paul Mandel,
Monique Jacob
Department of Pharmacology and the Beaumont-May Institute of Neurology, Washington University School of Medicine, St. Louis, USA
Robert Main Burton
Department of Physiology School of Medicine, Keio University, Tokyo, Japan
Yasuzo Tsukada
Institute of Biochemistry, Academy of Sciences of Armenian S.S.R., Yerevan, Armenia S.S.R.
Hrachia Chachatur Buniatian
Bibliographic Information
Book Title: Metabolic Turnover in the Nervous System
Authors: Sidney Roberts, P. Greengard, J. M. Ritchie, Michael M. Brand, G. M. Lehrer, Margaret R. Murray, N. Marks, A. Lajtha, R. Rodnight, Paul Mandel, Monique Jacob, Robert Main Burton, Yasuzo Tsukada, Hrachia Chachatur Buniatian, … Sze-Chuh Cheng
