Skip to main content
SpringerLink
Log in

Immunological Mechanisms and Therapies in Brain Injuries and Stroke

  • Book
  • © 2014

Overview

Editors:
  1. Jun Chen

    1. University of Pittsburgh School of Medicine, Pittsburgh, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Xiaoming Hu

    1. Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  3. Mary Stenzel-Poore

    1. Molecular Microbiology & Immunology, Oregon Health & Sciences University, Portland, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  4. John H. Zhang

    1. Loma Linda University, Loma Linda, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Explores the role of inflammation and immunological mechanisms in protecting the CNS during injury
  • Looks at translational and clinical research
  • Provides a comprehensive up-to-date overview
  • Includes supplementary material: sn.pub/extras

Part of the book series: Springer Series in Translational Stroke Research (SSTSR, volume 6)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (19 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Old Dogmas, Surprising Complexities, and Novel Therapeutic Targets

    • Ulrich Dirnagl
    Pages 1-8

  3. The Critical Roles of Immune Cells in Acute Brain Injuries

    • Peiying Li, Yu Gan, Leilei Mao, Rehana Leak, Jun Chen, Xiaoming Hu
    Pages 9-25

  4. Vascular Inflammation in Ischemic Stroke: Adhesion Receptors Controlling Leukocyte–Endothelial Interactions

    • Stephen F. Rodrigues, D. Neil Granger
    Pages 27-51

  5. Immune Cell-Derived Free Radicals in Acute Brain Injury

    • Purnima Narasimhan, Hiroyuki Sakata, Joo Eun Jung, Tatsuro Nishi, Takuma Wakai, Carolina M. Maier et al.
    Pages 53-66

  6. The Complement Cascade in Acute Brain Injury

    • Michael McDowell, Nicholas Shea, Gaurav Gupta, E. Sander Connolly Jr.
    Pages 67-85

  7. Matrix Metalloproteinases as an Inflammatory Mediator in the Neurovascular Unit

    • Changhong Xing, Takakuni Maki, Ji Hae Seo, Ken Arai, Eng H. Lo
    Pages 87-96

  8. Toll-Like Receptors in Ischemic Stroke and Other Acute Brain Injuries

    • Frances Rena Bahjat, Raffaella Gesuete, Mary P. Stenzel-Poore
    Pages 97-120

  9. Ion Transporters in Microglial Function: New Therapeutic Targets for Neuroinflammation in Ischemic Stroke?

    • Hui Yuan, Yejie Shi, Dandan Sun
    Pages 121-134

  10. Inflammation After Acute Brain Injuries Affects the Developing Brain Differently than the Adult Brain

    • David Fernández-López, Zinaida S. Vexler
    Pages 135-152

  11. Systemic Immune Responses after Experimental Stroke

    • Halina Offner, Patricia D. Hurn
    Pages 153-176

  12. Infectious Burden and Risk of Stroke

    • Jorge M. Luna, Mitchell S. V. Elkind
    Pages 177-210

  13. Inflammatory Biomarkers in Patients with Acute Brain Injuries

    • Glen C. Jickling
    Pages 211-234

  14. In Vivo Imaging of Neuroinflammation in Acute Brain Injury

    • Alexander Thiel
    Pages 235-248

  15. Inflammation as a Therapeutic Target after Subarachnoid Hemorrhage: Advances and Challenges

    • Mutsumi Fujii, Sheng Chen, Damon Klebe, Yoshiteru Soejima, Alexander Vakhmyanin, John H. Zhang
    Pages 249-274

  16. Minocycline, A Tetracycline Derivative, as a Potential Protective Agent for Acute Stroke

    • Jari Koistinaho, Milla Koistinaho
    Pages 275-285

  17. Tolerization to Brain and Vascular Antigens: Targeting Autoimmunity After Acute Brain Injuries and Preventing Stroke

    • Kyra J. Becker, John Hallenbeck
    Pages 287-299

  18. The Role of PPARγ in Stroke

    • Xiurong Zhao, Jaroslaw Aronowski
    Pages 301-320

  19. CD36: An Inflammatory Mediator in Acute Brain Injury

    • Sunghee Cho, Maria Febbraio
    Pages 321-347

  20. Cool Down the Inflammation: Hypothermia as a Therapeutic Strategy for Acute Brain Injuries

    • Yama Akbari, Maximilian Mulder, Ali Razmara, Romergryko Geocadin
    Pages 349-375
Back to top

Keywords

About this book

Recent research has revealed the importance of immunological mechanisms and inflammation in delaying damage and/or promoting repair after an acute injury to the central nervous system.  This book provides a comprehensive and up-to-date overview of the role of immunological mechanisms and therapies for treating acute neurological injuries such as cerebral ischemia, hemorrhage, and brain and spinal cord trauma. In several sections, the contributing authors provide a review of immunological mechanisms involved in neurological injury and of various translational and clinical research aimed at harnessing those mechanisms for better patient outcomes.​

Reviews

“This is an outstanding book on immune molecular and cellular treatment for brain injury and ischemia. … I recommend this book for all brain injury, stroke, and trauma investigators. This monograph is well written and profusely covered with pictures and postmortem slides reinforcing the concepts discussed. Students of Neurology and Neurosurgery will also find this a useful reference and stand alone book.” (Joseph J. Grenier, Amazon.com, October, 2015)

Editors and Affiliations

  • University of Pittsburgh School of Medicine, Pittsburgh, USA

    Jun Chen

  • Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, USA

    Xiaoming Hu

  • Molecular Microbiology & Immunology, Oregon Health & Sciences University, Portland, USA

    Mary Stenzel-Poore

  • Loma Linda University, Loma Linda, USA

    John H. Zhang

Bibliographic Information

  • Book Title: Immunological Mechanisms and Therapies in Brain Injuries and Stroke

  • Editors: Jun Chen, Xiaoming Hu, Mary Stenzel-Poore, John H. Zhang

  • Series Title: Springer Series in Translational Stroke Research

  • DOI: https://doi.org/10.1007/978-1-4614-8915-3

  • Publisher: Springer New York, NY

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Science+Business Media New York 2014

  • Hardcover ISBN: 978-1-4614-8914-6Published: 10 November 2013

  • Softcover ISBN: 978-1-4939-4495-8Published: 23 August 2016

  • eBook ISBN: 978-1-4614-8915-3Published: 09 November 2013

  • Series ISSN: 2363-958X

  • Series E-ISSN: 2363-9598

  • Edition Number: 1

  • Number of Pages: X, 386

  • Number of Illustrations: 13 b/w illustrations, 21 illustrations in colour

  • Topics: Neurosciences, Neurology, Neurobiology

Publish with us

Policies and ethics

Back to top

Search

Navigation