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  • © 2014

Protein Deimination in Human Health and Disease

  • Provides a comprehensive book, which does not currently exist, on a rapidly developing field

  • Illustrates the connection between deimination and numerous illnesses, including auto-immune diseases, Alzheimer's, Parkinson's, Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis, cancer, periodontitis, glaucoma, spinal cord trauma and peripheral nerve injury

  • Includes contributions from authors in the US, Canada, Europe and Asia

  • Includes supplementary material: sn.pub/extras

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-xiii
  2. Physiological Pathways of PAD Activation and Citrullinated Epitope Generation

    • Amanda S. Rohrbach, Sanja Arandjelovic, Kerri A. Mowen
    Pages 1-24
  3. From Citrullination to Specific Immunity and Disease in Rheumatoid Arthritis

    • Aase Haj Hensvold, Gudrun Reynisdottir, Anca I. Catrina
    Pages 25-40
  4. Protein Citrullination: The Link Between Rheumatoid Arthritis and Periodontitis?

    • M. J. de Smit, J. Westra, W. Nesse, A. Vissink, A. J. van Winkelhoff, E. Brouwer
    Pages 69-82
  5. Neutrophils and Their Contribution to Autoimmunity in Rheumatoid Arthritis

    • Julia Spengler, Dagmar Scheel-Toellner
    Pages 97-111
  6. Importance of Citrullination on Hair Protein Molecular Assembly During Trichocytic Differentiation

    • Kenji Kizawa, Masaki Unno, Claus W. Heizmann, Hidenari Takahara
    Pages 129-148
  7. Deimination in the Peripheral Nervous System: A Wallflower Existence

    • Gerburg Keilhoff, Anthony P. Nicholas
    Pages 149-164
  8. Deimination in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

    • Claire Bradford, Anthony P. Nicholas, Nicola Woodroofe, Alison K. Cross
    Pages 165-185
  9. Deimination in Prion Diseases

    • Eun-Kyoung Choi, Byungki Jang, Akihito Ishigami, Naoki Maruyama, Richard I. Carp, Yong-Sun Kim
    Pages 219-235
  10. Deimination in Alzheimer’s Disease

    • Akihito Ishigami, Eun-Kyoung Choi, Yong-Sun Kim, Naoki Maruyama
    Pages 237-255
  11. Ongoing Studies of Deimination in Neurodegenerative Diseases Using the F95 Antibody

    • Anthony P. Nicholas, Liang Lu, Michael Heaven, Inga Kadish, Thomas van Groen, Mary Ann Accaviti-Loper et al.
    Pages 257-280
  12. The Role of Deimination as a Response to Trauma and Hypoxic Injury in the Developing CNS

    • Patrizia Ferretti, Sigrun Lange, Kin Pong U, Gennadij Raivich
    Pages 281-294
  13. Deimination in Ocular Tissues: Present and Future

    • Di Ding, Mabel Enriquez-Algeciras, Vera L. Bonilha, Sanjoy K. Bhattacharya
    Pages 295-303
  14. PAD Enzymes in Female Reproductive Tissues and Cancer Pathogenesis

    • Brian D. Cherrington, Sunish Mohanan, Scott A. Coonrod
    Pages 305-326
  15. The Role of Protein Deimination in Epigenetics

    • Jialiang Liang, Patrizia Casaccia
    Pages 327-345
  16. Identifying Citrullination Sites by Mass Spectrometry

    • Jennifer E. Grant, Hong Li
    Pages 347-365

About this book

Deimination is a relatively new post-translational modification of proteins, whose recognition is ever-increasing. First linked to the pathology of rheumatoid arthritis (RA), deimination is a process by which selected positively charged arginine amino acids are converted to neutral citrulline amino acids by the peptidyl arginine deiminase (PAD) family of enzymes.

Although the medical literature is rich with articles about the possible significance of deiminated proteins in RA, Protein Deimination in Human Health and Disease is the first publication to compile this knowledge and the growing amount of new information now known about the presence of deiminated proteins in the eye, skin, hair, gums, lung and nervous system, as well. As a result, this process has now been linked to numerous additional conditions besides RA, including cancer, glaucoma, Alzheimer's disease, Parkinson's disease, multiple sclerosis, spinal cord and peripheral nerve injury, Creutzfeldt-Jakob disease, among many others.

Chronicling the earliest studies of deimination up to the present, this volume distills what is currently known about citrullination of proteins in the human body and is the first book of its kind on the topic.

Editors and Affiliations

  • Department of Neurology, University of Alabama at Birmingham and The Birmingham Veterans Administration Medical Center, Birmingham, USA

    Anthony P. Nicholas

  • Bascom Palmer Eye Institute, University of Miami, MIAMI, USA

    Sanjoy K. Bhattacharya

Bibliographic Information

  • Book Title: Protein Deimination in Human Health and Disease

  • Editors: Anthony P. Nicholas, Sanjoy K. Bhattacharya

  • DOI: https://doi.org/10.1007/978-1-4614-8317-5

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media New York 2014

  • eBook ISBN: 978-1-4614-8317-5Published: 03 December 2013

  • Edition Number: 1

  • Number of Pages: XIII, 433

  • Number of Illustrations: 55 b/w illustrations, 75 illustrations in colour

  • Topics: Neurosciences, Immunology, Protein Science

Buy it now

Buying options

eBook USD 159.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Other ways to access