Logo - springer
Slogan - springer

Biomedical Sciences - Neuroscience | Neuron-Glia Interaction in Neuroinflammation

Neuron-Glia Interaction in Neuroinflammation

Series: Advances in Neurobiology, Vol. 7

Suzumura, Akio, Ikenaka, Kazuhiro (Eds.)

2013, X, 187 p. 25 illus., 24 illus. in color.

Available Formats:
eBook
Information

Springer eBooks may be purchased by end-customers only and are sold without copy protection (DRM free). Instead, all eBooks include personalized watermarks. This means you can read the Springer eBooks across numerous devices such as Laptops, eReaders, and tablets.

You can pay for Springer eBooks with Visa, Mastercard, American Express or Paypal.

After the purchase you can directly download the eBook file or read it online in our Springer eBook Reader. Furthermore your eBook will be stored in your MySpringer account. So you can always re-download your eBooks.

 
$149.00

(net) price for USA

ISBN 978-1-4614-8313-7

digitally watermarked, no DRM

Included Format: PDF and EPUB

download immediately after purchase


learn more about Springer eBooks

add to marked items

Hardcover
Information

Hardcover version

You can pay for Springer Books with Visa, Mastercard, American Express or Paypal.

Standard shipping is free of charge for individual customers.

 
$189.00

(net) price for USA

ISBN 978-1-4614-8312-0

free shipping for individuals worldwide

usually dispatched within 3 to 5 business days


add to marked items

  • Focuses on neuron-glia interaction of various aspects for understanding of neurological disorders
  • Discusses interactions between neurons and microglia during neuroinflammation
  • Written by experts in the field

Accumulation of glia, gliosis, in various neurological disorders is not a static scar, but actively involved in pathogenesis of various neurological and psychiatric disorders, where glial cells produce both inflammatory and neurotrophic factors. These factors may play a role in neuronal damage, but also have a protective and reparative function by inducing neuroinflammation. However, definition as well as the mechanisms of neuroinflammation is not yet clear. We first define acute, chronic and non-classical neuroinflammation.

Glial cells are activated by a variety of stimuli via receptors on glial cells. Toll like receptors (TLR) are one of these receptors. In response to harmful stimuli, neurons produce factors as either “eat-me” or “help-me” signals. These factors include cytokines, chemokines and damage-associated molecular pattern (DAMP). Some of them activate glial cells via TLR, and function to protect neurons or further induce neuroinflammation. Thus, the interaction between neuron-glia and glia-glia is a main feature of neuroinflammation. Glial cells communicate with other glial or neural cells via gap-junctions. The communication may also be important for the understanding of neuroinflammation. Oligodendrocytes-neurons communication may be critical in either myelination or demyelination. Damage of blood-brain barrier (BBB) is common feature of both inflammatory and degenerative neurological disorders. Thus, relation of BBB damage and functions of glial cell may also be important in the development of neuroinflammation. 

In this book, we focused on neuron-glia interaction of various aspects for understanding of pathophysiology of neuroinflammation in development of inflammatory as well as degenerative neurological disorders.

Content Level » Research

Keywords » microglia - neurodegeneration - neuroinflammation - neuron-glia interaction

Related subjects » Neurology - Neuroscience

Table of contents 

Acute, Chronic, and Non-classical Neuroinflammation: Definitions in a Changing Scientific Environment.- Neuroinflammation in Neurological Disorders.- Factors from Intact and Damaged Neurons.- Interactions between Neurons and Microglia During Neuroinflammation.- Neuron-Astrocyte Interactions in Neuroinflammation.- Neuron-oligodendrocyte Interactions in Neuroinflammation.- Neuron-glia Interaction via Neurotrophins.- Glial Communication via Gap Junction in Neuroinflammation.- Toll-Like Receptors and Neuroinflammation.- The Blood-Brain-Barrier in Neuroinflammation.

Popular Content within this publication 

 

Articles

Read this Book on Springerlink

Services for this book

New Book Alert

Get alerted on new Springer publications in the subject area of Neurosciences.