A number of diseases and conditions that occur primarily in remote rural or poor urban areas of low-income countries have traditionally been neglected by the neuroscience research community. These diseases and conditions affect the nervous system directly (sometimes with lethal consequences) and/or are associated with severe neurological sequels such as epilepsy, cognitive deficits, and sleep disruption. Several diseases also have the effect of promoting poverty by leaving sufferers unable to lead economically productive lives due to cognitive and behavioral disturbances or severe stigmatization. The pathogenesis of neural dysfunction in the diseases addressed in this book and their sequels remains unclear. Neuroscience of Neglected Diseases and Conditions makes available much needed information about how these diseases affect the human nervous system as well as to promote interest in further research. Further research into neglected diseases and conditions will uncover information that sheds light on more general topics of interest to the neuroscience research community.
THE “GLOBAL WORLD VILLAGE” AND NEGLECTED DISEASES 1. Overview on neglected nervous system diseases: past, present and perspectives The volume editors 2. Travel, migration and neglected tropical diseases Zeno Bisoffi, Dora Buonfrate and Andrea Angheben, Centre for Tropical Diseases, Sacro Cuore Hospital, Negrar, Verona, Italy 3. Stigma in neurological diseases at the Tropics Faustin Yepnjio, EN Tabah and Alfred Njamnshi, University of Yaoundé 1, Cameroon NEGLECTED INFECTIOUS DISEASES OF THE NERVOUS SYSTEM 4. Nematode infections: Neurological involvement and neurobiology Yukifumi Nawa, Khon Kaen, University, Bangkok, Thailand 5. Amoebiasis: Neurological involvement and neurobiology Naveed Ahmed Khan, Aga Khan University, Karachi, Pakistan 6. Neuroschistosomiasis Teresa Cristina A Ferrari, Universidade Federal de Minas Gerais, Brazil 7. Neurocysticercosis: Neurology and neurobiology Arturo Carpio, University of Cuenca, Ecuador and Agnes Fleury INNN, Mexico City 8. Onchocerciasis: Neurological involvement Alfred Njamnshi and AC Zoung-Kanyi Bissek, University of Yaoundé 1, Cameroon 9. Human African trypanosomiasis: A highly neglected neurological disease Alain Buguet, Polyclinique Marie-Louise Poto-Djembo, Pointe Noire, République du Congo, Ghislain Mpanzou, Clinique Municipale Albert Leyono, Brazzaville, République du Congo, and Marina Bentivoglio, University of Verona, Verona, Italy , 10. Human African trypanosomiasis: Neurobiology Willias Masocha, Krister Kristensson and Martin Rottenberg, University of Kuwait and Karolinska Institutet, Stockholm, Sweden 11. Chagas’ disease: Neurology and neurobiology José Rodrigues Coura, Federal University of Rio de Janeiro, Brazil 12. Neurodegeneration in leprosy: Insights from model systems and patients Toshihiro Masaki, Teikyo University, Tokyo, Japan, and Anura Rambukkana, University of Edinburgh, UK 13. Rabies: Neurology Alan Jackson, University of Manitoba, Canada– 14. Rabies : Neurobiology Monique Lafon, Pasteur Institute, Paris, France 15. Japanese encephalitis and other arbovirus infections: Neurology and neurobiology Usha Kant Misra and Jayantee Kalita, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India NEGLECTED TOXIC DISORDERS OF THE NERVOUS SYSTEM 16. Khat addiction: Neurology Michael Odenwald, University of Konstanz, Germany 17. Khat addiction: Neurobiology Nilesh Patel, University of Nairobi, Kenya 18. Konzo: neurology of a permanent and non-progressive motor neuron Daniel Okitundu, University of Kinshasa, DR Congo, Dieudonné Mumba, Tropical Medicine, University of Kinshasa & National Institute of Biomedical Research, DR Congo and Desire Tshala-Katumbay, Center for Research on Occupational & Environmental Toxicology, Portland, USA 19. Food preservation, snake venoms and stroke in the Tropics Albert Akpalu, University of Accra, Ghana SEQUELS AND CONSEQUENCES 20. Infectious causes of epilepsy? Charles R. Newton, Wellcome Trust, Kilifi, Kenya, Ryan G. Wagner, University of the Witwatersrand, South Africa 21. Cognitive impairment and behavioural disturbances following malaria or HIV infection in childhood Michael Kihara, Amina Abubakar, Charles RJC Newton, The Centre for Geographical Medicine Research (Coast), Kenya Medical Research Institute, Kilifi, Kenya