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Biomedical Sciences - Neuroscience | Prions and Diseases - Volume 2, Animals, Humans and the Environment

Prions and Diseases

Volume 2, Animals, Humans and the Environment

Zou, Wen-Quan, Gambetti, Pierluigi (Eds.)

2013, X, 298 p.

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  • Authored by a team of leading researchers and clinicians
  • Updated knowledge and concepts on pathogenic prion proteins and prion diseases
  • Present state-of the art findings and hypotheses beyond prions and prion diseases

Transmissible spongiform encephalopathies (TSE), now broadly known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. However, the nature of the transmissible agent had largely remained a mystery until Stanley Prusiner discovered the infectious isoform of the prion protein (PrP), named prion or scrapie PrP (PrPSc), in 1982. The subsequent modern studies with protein chemistry and molecular biology in cell culture, transgenic animals, and cell-free systems, including the revolutionary protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In Prions and Prion Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date development in many aspects of these unique infectious pathogens and their associated diseases.

Volume II features a variety of animal and human prion diseases, including the newly-identified atypical forms of bovine spongiform encephalopathy and scrapie in animals, and variably protease-sensitive prionopathy in humans, prions in the environment, Tau pathology in human prion disease, transmission of the disease by blood transfusion, mammalian and non-mammalian models, conventional and advanced diagnoses, prion-specific antibodies, as well as decontamination of prions and development of therapeutics of prion diseases, such as the application of immunomodulation. This volume provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the highly publicized animal and human prion diseases.

Content Level » Research

Keywords » Creutzfeldt-Jakob disease - Prion protein - bovine spongiform encephalopathy - chronic wasting disease - prion diseases - prions - scrapie

Related subjects » Animal Sciences - Biochemistry & Biophysics - Human Physiology - Neurology - Neuroscience

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