Prions and Diseases

1. Front Matter

   Pages i-ix

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2. Transmissible Spongiform Encephalopathy: From its Beginnings to Daniel Carlton Gajdusek

   • Paul Brown

   Pages 1-19

3. The Rich Chemistry of the Copper and Zinc Sites in Cellular Prion Protein

   • Glenn L. Millhauser

   Pages 21-34

4. Role of Cellular Prion Protein in the Amyloid-β Oligomer Pathophysiology of Alzheimer’s Disease

   • Adam C. Kaufman, Stephen M. Strittmatter

   Pages 35-48

5. Cellular Prion Protein and Cancers

   • Wei Xin, Man-sun Sy, Chaoyang Li

   Pages 49-66

6. Insoluble Cellular Prion Protein

   • Wen-Quan Zou

   Pages 67-82

7. Protein Misfolding Cyclic Amplification

   • Fabio Moda, Sandra Pritzkow, Claudio Soto

   Pages 83-92

8. Cofactor Involvement in Prion Propagation

   • Surachai Supattapone, Michael B. Miller

   Pages 93-105

9. Prion Protein Conversion and Lipids

   • Jiyan Ma

   Pages 107-119

10. New Perspectives on Prion Conversion: Introducing a Mechanism of Deformed Templating

    • Ilia V. Baskakov

    Pages 121-133

11. Infectious and Pathogenic Forms of PrP

    • Emiliano Biasini, David A. Harris

    Pages 135-146

12. Cellular Mechanisms of Propagation and Clearance

    • Hermann M. Schatzl

    Pages 147-160

13. Molecular Mechanisms Encoding Quantitative and Qualitative Traits of Prion Strains

    • Jiri G. Safar

    Pages 161-179

14. Modeling the Cell Biology of Prions

    • Richard Rubenstein, Robert B. Petersen

    Pages 181-192

15. Prion Strain Interference

    • Charles R. Schutt, Ronald A. Shikiya, Jason C. Bartz

    Pages 193-204

16. Introduction to Yeast and Fungal Prions

    • Reed B. Wickner

    Pages 205-215

17. Yeast Prions Are Pathogenic, In-Register Parallel Amyloids

    • Reed B. Wickner, Herman K. Edskes, David A. Bateman, Amy C. Kelly, Anton Gorkovskiy

    Pages 217-231

18. Back Matter

    Pages 233-241

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Volume I highlights the association of the cellular prion protein (PrP^C) with copper and zinc, the potential roles of PrP^C in Alzheimer’s disease and cancers, insoluble PrP^C, PMCA, molecular and cellular mechanisms of PrP^Sc formation and clearance, possible co-factors involved in the conversion of PrP^C into PrP^Sc, infectious and pathogenic forms of PrP, cell biology of prions, prion strains and their interference, as well as yeast prions and their inheritable and structural traits. This unique volume will take you through the fascinating chronicle of prions in mammals, yeast, and fungi.

• Creutzfeldt-Jakob disease
• Prion protein
• bovine spongiform encephalopathy
• chronic wasting disease
• prion diseases
• prions
• scrapie

• , Department of Pathology, Case Western Reserve University School o, Cleveland, USA

  Wen-Quan Zou

• , Department of Neuropathology, Case Western Reserve University School o, Cleveland, USA

  Pierluigi Gambetti

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