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Biomedical Sciences - Neuroscience | endoCANNABINOIDS - Actions at Non-CB1/CB2 Cannabinoid Receptors


Actions at Non-CB1/CB2 Cannabinoid Receptors

Series: The Receptors, Vol. 24

Abood, Mary E., Sorensen, Roger G, Stella, Nephi (Eds.)

2013, XII, 288 p.

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  • Research provided by leading scientists
  • Complement recent texts that describe cannabinoids, the endocannabinoid system, the physiological roles of cannabinoids as mediated through their actions at cannabinoid receptors, and the therapeutic potential of compounds that modulate CB1 and CB2 receptor function
  • Cutting-edge research presented in accessible manner

The cloning of two G protein-coupled cannabinoid receptors, termed CB1 and CB2, in the early 1990s has stimulated and facilitated research conducted on the physiological function of cannabinoid actions in the brain and throughout the body. In the twenty years since the identification of these two receptors, endogenous ligands (endocannabinoids) for these receptors have been identified, their biosynthetic and metabolic pathways have been discerned, and their functional and regulatory action for signalling through CB1 and CB2 receptors have been described. More recently, it has become has become evident that cannabinoids exert actions at non-CB1, non-CB2 receptors. Much less is understood about these actions. Many of these novel “targets” are in the process of being characterized functionally and physiologically, and the therapeutic value of targeting these non-CB1, non-CB2 receptors is being evaluated. The purpose of this volume is to present the current knowledge on the atypical actions of cannabinoids on these new targets.


This book is intended as a scientific resource for cannabinoid researchers carrying out animal and human experiments, and for those who are interested in learning about future directions in cannabinoid research. Additionally, this book may be of value to investigators currently working outside the field of cannabinoid research who have an interest in learning about these compounds and their atypical cannabinoid signalling. This book provides insight into the potential medical application of cannabinoids and their therapeutic development for the treatment of human disease.

Content Level » Research

Keywords » animal research - atypical endocannabinoid actions - atypical endocannabinoid receptors - cannabinoids - endocannabinoids - human research - neuroscience - physiological function

Related subjects » Animal Sciences - Human Physiology - Neuroscience - Pharmacology & Toxicology

Table of contents 

PART I: Overview of Non-Cannabinoid Receptors

Chapter 1: Overview of Non-Classical Cannabinoid Receptors
Grzegorz Godlewski and George Kunos

Chapter 2: Overview of Non-Cannabinoid Receptors: Chemistry and Modeling
Evangelia Kotsikorou and Patricia Reggio

PART II: G-Protein Coupled Receptors

Chapter 3: GPR55 in the CNS
Hui-Chen Lu, Jane E. Lauckner, John W. Huffman, Ken Mackie

Chapter 4: The Role of GPR55 in Bone Biology
Lauren S. Whyte and Ruth A. Ross

Chapter 5: The Role of GPR55 in Cancer
Clara Andradas, María M Caffarel, Eduardo Pérez-Gómez, Manuel Guzmán and Cristina Sánchez

Chapter 6: GPR18 and NAGly signaling: New members of the endocannabinoid family or distant cousins?
Douglas McHugh and Heather B Bradshaw

Chapter 7: Cannabinoid Signaling Through Non CB1/Non CB2 GPCR Targets in Microglia
Neta Rimmerman, Ewa Kozela, Rivka Levy, Zvi Vogel, Ana Juknat

PART III: Ion Channels

Chapter 8: Temperature-Sensitive Transient Receptor Potential Channels as Ionotropic Cannabinoid Receptors
Vincenzo Di Marzo and Luciano De Petrocellis

Chapter 9: Nonpsychoactive Cannabinoid Action on 5-HT3 and Glycine Receptors
Li Zhang and Wei Xiong

PART IV: Transcription Factors

Chapter 10: Peroxisome proliferator-activated receptors and inflammation
James Burston and David Kendall

Chapter 11: Peroxisome proliferator-activated nuclear receptors (PPAR) and drug addiction
Paola Mascia, Gianluigi Tanda, Sevil Yasar, Stephen J. Heishman and Steven R. Goldberg

PART V: Conclusions/Therapeutic Potential

Chapter 12: Conclusions: Therapeutic Potential of Novel Cannabinoid Receptors
Mary Abood, Roger Sorensen and Nephi Stella

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