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Metal Ion in Stroke

  • Book
  • © 2012

Overview

Editors:
  1. Yang V. Li

    1. , Department of Biomedical Sciences, Ohio University, Athens, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. John H. Zhang

    1. Loma Linda University, Loma Linda, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Details the cellular events that occur following stroke
  • For the first time, the dyshomeostasis and pathophysiological actions of these metals in stroke are discussed systematically in one volume.
  • Many metals function as co-factors in cellular and genetic signaling and, therefore, have important roles in biochemistry ranging from essential to toxic

Part of the book series: Springer Series in Translational Stroke Research (SSTSR)

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About this book

Stroke is a major cause of death and disability in the U.S. and worldwide. A variety of pathophysiologic episodes or cellular medications occur following a stroke, and knowledge of these aftermath events can lead to potential therapeutic strategies that may reverse or attenuate stroke injury. Cellular events that occur following stroke include the excessive releases of excitatory amino acids, alterations in the genomic responses, mitochondrial injury producing reactive oxygen and nitrogen species (ROS), and secondary injury, often in the setting of reperfusion.

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Table of contents (36 chapters)

  1. Front Matter

    Pages i-xvii
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  2. Metal Ions in Stroke Pathophysiology

    • Yang V. Li, John H. Zhang
    Pages 1-12

  3. Calcium (Ca)

    1. Front Matter

      Pages 13-13
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    2. Mechanisms of Calcium Influx Following Stroke

      • Jillian C. Belrose, Fabiana A. Caetano, Kai Yang, Brian M. W. Lockhart, Michael F. Jackson, John F. MacDonald
      Pages 15-39

    3. Mitochondrial Ca2+ Dysregulation During Stroke and Cell Death

      • Maria Josè Sisalli, Claudia Savoia, Antonella Scorziello
      Pages 41-67

    4. Calcium Channel Blockers and Stroke Prevention

      • Anna Poggesi, Domenico Inzitari
      Pages 69-101

    5. Calcium Dyshomeostasis in Astrocytes After Ischemia

      • Elena Alberdi, María Domercq, Carlos Matute
      Pages 103-127

    6. Calcium Signaling at the Blood–Brain Barrier in Stroke

      • Rachel C. Brown
      Pages 129-163

  4. Zinc (Zn)

    1. Front Matter

      Pages 165-165
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  5. Zinc in Stroke Pathophysiology

    1. Zinc Overload in Stroke

      • Yang V. Li
      Pages 167-189

    2. Intracellular Zinc Liberation: A Trigger for Oxidative Stress-Induced Toxicity to Neurons and Neuroglia

      • Yumin Zhang
      Pages 191-208

    3. Zinc in Stroke: Time for a New Approach?

      • Richard B. Thompson
      Pages 209-226

    4. Exploring the Zinc Metallome of Cultured Cortical Neurons Using Synchroton Radiation X-Ray Fluorescence Microscopy

      • Robert A. Colvin, Christian J. Stork, Yang V. Li, Barry Lai
      Pages 227-237

  6. Iron (Fe)

    1. Front Matter

      Pages 239-239
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    2. Iron Neurotoxicity in Ischemic and Hemorrhagic Stroke

      • Chih Ming Lin, Magdy Selim
      Pages 241-253

    3. Implication of Oxidative Stress and “Labile Iron” in the Molecular Mechanisms of Ischemic Stroke

      • Dimitrios Galaris, Natalia Kitsati, Sygkliti-Henrietta Pelidou, Alexandra Barbouti
      Pages 255-271

    4. The Role of Iron in Brain Following Subarachnoid Hemorrhage

      • Jin-Yul Lee, Richard F. Keep, Ya Hua, Aditya Pandey, Guohua Xi
      Pages 273-282

    5. Iron-Chelating Therapy in Stroke

      • Mónica Millán, Natalia Pérez de la Ossa, Teresa Gasull
      Pages 283-301

  7. Sodium (Na)

    1. Front Matter

      Pages 303-303
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  8. Sodium (Na)

    1. The Role of Na+/Ca2+ Countertransport and Other Na+-Entry Routes in the Pathophysiology of Stroke

      • Mauro Cataldi, Pasquale Molinaro, Lucio Annunziato
      Pages 305-331
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Reviews

From the reviews:

“This is a comprehensive book about the role of ions and anions in neurotransmission, cerebral ischemia, subarachnoid hemorrhage, trauma etc. Each chapter is devoted to the indication of mediators related to channel and mitochondrial pathophysiology. … I recommend this book to neurologists, neurosurgeons, biochemists, and neurophysiologists. Students will be greatly helped by this book, showing that cofactors can be toxic, but at micromolar ranges be beneficial to the stroked brain in small vessel disease.” (Joseph J. Grenier, Amazon.com, May, 2014)

Editors and Affiliations

  • , Department of Biomedical Sciences, Ohio University, Athens, USA

    Yang V. Li

  • Loma Linda University, Loma Linda, USA

    John H. Zhang

Bibliographic Information

  • Book Title: Metal Ion in Stroke

  • Editors: Yang V. Li, John H. Zhang

  • Series Title: Springer Series in Translational Stroke Research

  • DOI: https://doi.org/10.1007/978-1-4419-9663-3

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media New York 2012

  • Hardcover ISBN: 978-1-4419-9662-6Published: 17 May 2012

  • Softcover ISBN: 978-1-4939-4149-0Published: 23 August 2016

  • eBook ISBN: 978-1-4419-9663-3Published: 15 June 2012

  • Series ISSN: 2363-958X

  • Series E-ISSN: 2363-9598

  • Edition Number: 1

  • Number of Pages: XVII, 820

  • Topics: Neurosciences

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