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Translational Stroke Research

From Target Selection to Clinical Trials

  • Book
  • © 2012

Overview

Editors:
  1. Paul A. Lapchak

    1. , Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. John H. Zhang

    1. Loma Linda University, Loma Linda, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Sets a basis for effective translational research
  • Emphasis is placed on target identification and drug development using state-of-the-art in vitro and in vivo assays
  • Each chapter specifically addresses one or more components of preclinical stroke research

Part of the book series: Springer Series in Translational Stroke Research (SSTSR)

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Table of contents (43 chapters)

  1. Front Matter

    Pages i-xxiv
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  2. Theoretical Overview

    1. Front Matter

      Pages 1-1
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  3. THEORETICAL OVERVIEW

    1. Vascular Targets for Ischemic Stroke Treatment

      • Sara Morales Palomares, Marilyn J. Cipolla
      Pages 3-36

    2. Identifying Vascular Targets to Treat Hemorrhagic Stroke

      • Paul A. Lapchak
      Pages 37-55

    3. Experimental Platforms for Assessing White Matter Pathophysiology in Stroke

      • Ken Arai, Loc-Duyen D. Pham, Eng H. Lo
      Pages 57-78

    4. Neuroprotection in Stroke

      • Aarti Sarwal, Muhammad Shazam Hussain, Ashfaq Shuaib
      Pages 79-97

  4. Mechanisms and Targets

    1. Front Matter

      Pages 99-99
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  5. MECHANISMS & TARGETS

    1. Protein Aggregation and Multiple Organelle Damage After Brain Ischemia

      • Chunli H. Liu, Fan Zhang, Tibor Krisrian, Brian Polster, Gary M. Fiskum, Bingren Hu
      Pages 101-116

    2. Antioxidants and Stroke: Success and Pitfalls

      • Fernanda M. F. Roleira, Elisiário J. Tavares-da-Silva, Jorge Garrido, Fernanda Borges
      Pages 117-143

    3. Caspase-Independent Stroke Targets

      • Ruoyang Shi, Jiequn Weng, Paul Szelemej, Jiming Kong
      Pages 145-174

    4. Hypoxia-Inducible Factor: A New Hope to Counteract Stroke

      • Chunhua Chen, Changman Zhou
      Pages 175-188

    5. Thrombin in Ischemic Stroke Targeting

      • Bo Chen
      Pages 189-204

    6. Toll-Like Receptor Agonists as Antecedent Therapy for Ischemic Brain Injury: Advancing Preclinical Studies to the Nonhuman Primate

      • Frances Rena Bahjat, Keri B. Vartanian, G. Alexander West, Mary P. Stenzel-Poore
      Pages 205-230

    7. Angiogenesis and Arteriogenesis as Stroke Targets

      • Jieli Chen, Michael Chopp
      Pages 231-249

    8. Hematopoietic Growth Factor Family for Stroke Drug Development

      • Ihsan Solaroglu, Murat Digicaylioglu
      Pages 251-276

    9. Soluble Epoxide Hydrolase as a Stroke Target

      • Jonathan W. Nelson, Nabil J. Alkayed
      Pages 277-294

    10. Membrane Potential as Stroke Target

      • Jens P. Dreier, Maren Winkler, Dirk Wiesenthal, Michael Scheel, Clemens Reiffurth
      Pages 295-303

    11. Hypothermia to Identify Therapeutic Targets for Stroke Treatment

      • Masaaki Hokari, Midori A. Yenari
      Pages 305-320

    12. Stroke Preconditioning to Identify Endogenous Protective or Regenerative Mechanisms

      • Liren Qian, Prativa Sherchan, Xuejun Sun
      Pages 321-334

    13. microRNAs in Ischemic Brain: The Fine-Tuning Specialists and Novel Therapeutic Targets

      • Ashutosh Dharap, Venkata P. Nakka, Raghu Vemuganti
      Pages 335-352
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About this book

This volume sets a basis for effective translational research. Authored by experts in the field of translational stroke research, each chapter specifically addresses one or more components of preclinical stroke research. The emphasis is placed on target identification and drug development using state-of-the-art in vitro and in vivo assays, in combination with in vitro toxicology assays, AMDE and clinical design.

Reviews

From the reviews:

“This book is an excellent review of cerebral hemorrhage, ischemia, and hypoxia as it involves pathology, pathophysiology, and cellular tolerance. It will appeal to a wide variety of investigators in stroke, neurology, and neurosurgery research. I highly recommend it in Neurology Research.” (Joseph J. Grenier, Amazon.com, February, 2014)

“In Translational Stroke Research, Lapchak and Zhang have gathered an impressive, and very large, assortment of clinicians and researchers from around the world to offer reports of their studies, new ideas … and directions for future research based mainly on pleotropic and combined therapies. … The authors are to be congratulated on a great effort in furthering the available information and pitfalls in this field and pointing researchers and practitioners in a clinically significant direction. … It makes for fascinating reading!” (Elizabeth A. M. Frost, Journal of Neurosurgical Anesthesiology, Vol. 24 (4), October, 2012)

Editors and Affiliations

  • , Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, USA

    Paul A. Lapchak

  • Loma Linda University, Loma Linda, USA

    John H. Zhang

Bibliographic Information

  • Book Title: Translational Stroke Research

  • Book Subtitle: From Target Selection to Clinical Trials

  • Editors: Paul A. Lapchak, John H. Zhang

  • Series Title: Springer Series in Translational Stroke Research

  • DOI: https://doi.org/10.1007/978-1-4419-9530-8

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media, LLC 2012

  • Hardcover ISBN: 978-1-4419-9529-2Published: 23 March 2012

  • Softcover ISBN: 978-1-4939-4138-4Published: 23 August 2016

  • eBook ISBN: 978-1-4419-9530-8Published: 22 March 2012

  • Series ISSN: 2363-958X

  • Series E-ISSN: 2363-9598

  • Edition Number: 1

  • Number of Pages: XXIV, 923

  • Topics: Neurosciences, Neurobiology

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