Gene Therapy for Neurological Disorders and Brain Tumors

1. Front Matter

   Pages i-xi

   PDF

2. Vectors and Promoters

   1. Front Matter

      Pages 1-6

      PDF

   2. Retrovirus Vectors and Regulatable Promoters

      • Steven A. Reeves

      Pages 7-38

   3. Characteristics of Adenovirus Vectors

      • Susanna Chiocca, Matt Cotten

      Pages 39-52

   4. HSV Recombinant Vectors

      • Paul A. Johnson

      Pages 53-62

   5. HSV-1 Amplicon

      • Cornel Fraefel, Xandra O. Breakefield, David R. Jacoby

      Pages 63-82

   6. AAV Vectors

      • Frances I. Smith, Thomas J. McCown

      Pages 83-92

   7. EBV Vectors

      • Jean-Michel H. Vos, Keith B. Quattrocchi, Brian J. Wendelburg

      Pages 93-112

   8. Lentiviral Vectors for Gene Delivery in the Nervous System

      • Didier Trono, Ulrike Blömer, Luigi Naldini

      Pages 113-120

   9. Promoters for Expression of Gene Products within Neurons and Glia

      • John W. Henson

      Pages 121-146

   10. Immune Response to Viral Vectors

       • Jason G. Smith, Stephen L. Eck

       Pages 147-157

3. Neuro-Oncology

   1. Front Matter

      Pages 159-159

      PDF

   2. Current Treatment Modalities for Brain Tumor

      • Stephen B. Tatter, Griffith R. Harsh IV

      Pages 161-189

   3. Experimental and Clinical Gene Therapies for Brain Tumors

      • E. Antonio Chiocca

      Pages 191-203

   4. Tumor Suppressor Gene Therapy for Brain Tumors

      • Candelaria Gomez-Manzano, Juan Fueyo, Athanassios P. Kyritsis, W. K. Alfred Yung

      Pages 205-229

   5. Cytokine-Based Gene Therapy for Brain Tumors

      • John H. Sampson, Darell D. Bigner, Glenn Dranoff

      Pages 231-294

   6. Delivery of Therapeutic Genes to Brain and Intracerebral Tumors

      • Leslie L. Muldoon, Robert A. Kroll, Michael A. Pagel, Simon Roman-Goldstein, Edward A. Neuwelt

      Pages 295-312

   7. Rat Brain Tumor Models and the Statistical Evaluation of Survival Data in Experimental Neuro-Oncology

      • Rolf F. Barth, Melvin L. Moeschberger

      Pages 313-337

4. Neurological Diseases

   1. Front Matter

      Pages 339-343

      PDF

   2. Gene Transfer for Adult CNS Regeneration and Aging

      • Marie-Claude Senut, Isabelle Aubert, Philip J. Horner, Fred H. Gage

      Pages 345-375

Leading gene therapy researchers and clinicians illuminate the field-from basic vector technology to current and future clinical applications in neurology. The authoritative contributors provide cutting-edge reviews of the vectors available for gene transfer to the central nervous system, the strategies against CNS tumors, the potential strategies against neurologic disorder, and the limitations of today's gene therapy approaches. Also discussed are significant applications of gene therapy to brain tumors, Parkinson's disease, ischemia, and Huntington's chorea. Readers will learn the current delivery methods for transgenes, will learn the characteristics of transgene delivery vectors, and come to understand the therapy for both neuro-oncologic and neurologic disorders.

• Bur
• Nervous System
• Neurology
• Parkinson
• Promoter
• genes
• neurons
• surgery

"a very interesting book. . .all 'gene therapy laboratories' and 'neuo-gene therapy laboratories' will be able to derive much intellectual nourishment and stimulation, practical tips, and predictions about the future from this truly challenging volume."-Human Genetics

• Molecular Neuro-Oncology, Neurosurgical Service, Massachussetts General Hospital, Harvard Medical School, Boston, USA

  E. Antonio Chiocca

• Neurogenetics Unit, Massachussetts General Hospital, Harvard Medical Center, Boston, USA

  Xandra O. Breakefield

Policies and ethics