Neurotransmitters and Epilepsy

1. Front Matter

   Pages i-xviii

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2. Neurotransmitter Systems and Epilepsy

   • John W. Dailey, Phillip C. Jobe

   Pages 1-7

3. Epilepsy-Prone Mice

   • A. G. Chapman, B. S. Meldrum

   Pages 9-40

4. The Spontaneously Epileptic Mongolian Gerbil

   • Peter Lomax, Randall J. Lee, Richard W. Olsen

   Pages 41-56

5. The Genetically Epilepsy-Prone Rat

   • Hugh E. Laird II, Phillip C. Jobe

   Pages 57-94

6. The Epileptic Chickens

   • D. D. Johnson, J. M. Tuchek

   Pages 95-114

7. Biochemical and Pharmacologic Studies of Neurotransmitters in the Kindling Model

   • James O. McNamara, Douglas W. Bonhaus, Barbara J. Crain, Randy L. Gellman, Cheolsu Shin

   Pages 115-160

8. In Vitro Models of Epilepsy

   • Roger D. Traub, Robert K. S. Wong, Richard Miles

   Pages 161-190

9. Experimental Epilepsy Induced By Direct Topical Placement of Chemical Agents on the Cerebral Cortex

   • Charles R. Craig, Brenda K. Colasanti

   Pages 191-214

10. Seizures Induced by Convulsant Drugs

    • Carl L. Faingold

    Pages 215-276

11. The Role of Neurotransmitters in Electroshock Seizure Models

    • Ronald A. Browning

    Pages 277-320

12. Neurotransmitters in Human Epilepsy

    • Mitchell J. Kresch, Bennett A. Shaywitz, Sally E. Shaywitz, George M. Anderson, James L. Leckman, Donald J. Cohen

    Pages 321-338

13. Neurotransmitter Systems and the Epilepsy Models

    • Phillip C. Jobe, Hugh E. Laird II

    Pages 339-366

14. Back Matter

    Pages 367-376

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The idea for this book has evolved from our desire to present a conceptual approach to the study of neurotransmitters in epilepsy. Such an approach requires an understanding of the function of neurotransmitter systems in various experimental models of epilep­ sy. Toward this goal we have included in this book chapters on neurotransmitter systems in nine different epilepsy models. To com­ plete the coverage of this topic, there is a chapter on the role of selected neurotransmitters in the various types of human epilep­ sies. In the final chapter the editors integrated the neurotransmit­ ter data from the various epilepsy models into a matrix from which a better understanding of the function of these neurotransmitters in modulating epileptogenesis may be obtained. The information found in this book is not the result of a sym­ posium on this topic, but rather a review of available information on neurotransmitters in each of the experimental models. The evi­ dence is presented by knowledgeable researchers using these models. This approach gives a current, broader, and more thorough presentation of each of the topics. We therefore feel that this is not just a glimpse at the subject matter, but a panoramic view of the topic.

• cerebral cortex
• cortex
• epilepsy
• neurotransmitter

• Department of Basic Sciences, College of Medicine at Peoria, University of Illinois, Peoria, USA

  Phillip C. Jobe

• Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, USA

  Hugh E. Laird

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