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Considers both animal and human studies and integrates them into statements of mechanisms and biochemical alterations and treatments
Contains the most commonly seen metabolic encephalopathies and those in which the diagnosis and treatment have advanced and benefited from technological studies
Metabolic Encephalopathy is meant to combine and correlate animal and human studies. In many cases, alterations in the neurochemistry of humans and experimental animal models is similar. It is hoped that increased awareness of the importance of early diagnosis and treatment of these disorders may result in a lowering of the incidence of structural changes and morbidity. These metabolic encephalopathies hold a special fascination for both basic scientists and clinical investigators because they are accessible, treatable, and there exist good animal models for further study. Therefore, this book assembles both basic and clinical neuroscience issues in the treatment of specific metabolic encephalopathies such as uremia, Wernicke’s disease, epilepsy, stroke, hepatic encephalopathy, pediatric encephalopathies, inborn errors of metabolism, toxins such as lead, depression, cerebral infections, kernicterus, Wilson disease, and many others.
About the Editor:
Dr. David W. McCandless is the John J. Sheinin Professor of Anatomy in the Department of Cell Biology and Anatomy at The Chicago Medical School, Rosalind Franklin University, North Chicago, IL. He has over 35 years of laboratory research into basic mechanisms of various metabolic encephalopathies. He serves as Editor-in Chief of the journal Metabolic Brain Disease (Springer), now in its 23rd year. Dr. McCandless has been on the faculty or research staff at The University of Vermont College of Medicine, NIH-NINCDS, University of Texas Medical School at Houston, and The Chicago Medical School, and was a visiting professor at Washington University School of Medicine. Dr. McCandless has published in journals such as The J. Clinical Investigation, Nature, Proc. National Academy of Sciences, Amer. J. of Physiology, Brain Research, J. Neurochemistry, Teratology, Epilepsia, Stroke, and many others. This is his third edited book.
Preface. David.W. McCandless.- 1. Functional Anatomy of the Brain. John M. DeSesso.- 2. Brain Metabolic Adaptations to Hypoxia. Michelle A. Puchowicz, Smruta S. Koppaka, and Joseph C. LaManna.- 3. Hypoglycemic Brain Damage.- Roland N. Auer.- 4. Experimental Ischemia: Summary of Metabolic Encephalopathy. W. David Lust, Jennifer Zechel, and Svetlana Pundik.- 5. Stroke—Clinical Features. Svetlana Pundik, and Jose I. Suarez.- 6. The Role of Animal Models in the Study of Epileptogenesis. Kate Chandler, Pi-Shan Chang, and Matthew Walker.- 7. Seizure-Induced Neuronal Plasticity and Metabolic Effects. Monisha Goyal.- 8. Metabolic Encephalopathies in Children. Joseph DiCarlo.- 9. Pathophysiology of Hepatic Encephalopathy: Studies in Animal Models. Roger F. Butterworth.- 10. Hepatic Encephalopathy. Karin Weissenborn.- 11. Uremic and Dialysis Encephalopathies. Allen I. Arieff.- 12. Thiamine Deficiency: A Model of Metabolic Encephalopathy and of Selective Neuronal Vulnerability. Saravanan Karuppagounder and Gary E. Gibson.- 13. Alcohol, Apoptosis, and Oxidative Stress. George I Henderson, Jennifer Stewart, and Steven Schenker.- 14. Wernicke’s Encephalopathy. Maryam R. Kashi, George I Henderson, and Steven Schenker.- 15. The Genetics of Myelination in Metabolic Brain Disease: The Leukodystrophies. John W. Rumsey.- 16. Bilirubin Encephalopathy. Jeffrey W. McCandless and David W McCandless.- 17. Infectious And Inflammatory Metabolic Encephalopathies: Concepts in Pathogenesis. Kottil Rammohan.- 18. Major Depression and Metabolic Encephalopathy: Syndromes More Alike Than Not? Brian H. Harvey.- 19. Attention-deficit/hyperactivity Disorder as a Metabolic Encephalopathy. Vivienne Ann Russell.- 20. Brain Damage in Phenylalanine, Homocysteine, and Galactose Metabolic Disorders. Kleopatra H.Schulpis and Stylianos Tsakiris.- 21. Wilson Disease. Peter Ferenci.- 22. Metabolic Abnormalities in Alzheimer Disease. Florian M. Gebhardt and Peter R Dodd.- 23. Prions and the Transmissible Spongiform Encephalopathies. Richard C. Wiggins.- 24. Lead Encephalopathy. Ivan J. Boyer.- Index.