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Hypocretins

Integrators of Physiological Signals

  • Book
  • © 2005

Overview

Editors:
  1. Luis Lecea

    1. The Scripps Research Institute, La Jolla, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. J. Gregor Sutcliffe

    1. The Scripps Research Institute, La Jolla, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Represents an interdisciplinary approach to hypocretins that reviews the role of these neuropeptides in neurological disease

  • Includes supplementary material: sn.pub/extras

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Table of contents (28 chapters)

  1. Front Matter

    Pages i-xxiii
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  2. Discovery of the Hypocretins/Orexins and Their Receptors

    1. Front Matter

      Pages 1-1
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    2. The Discovery of the Hypocretins

      • Luis de Lecea, J. Gregor Sutcliffe
      Pages 3-11

    3. Orexin and Orexin Receptors

      • Takeshi Sakurai
      Pages 13-23

  3. Animal Models in the Study of the Hypocretinergic System

    1. Front Matter

      Pages 25-25
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    2. Rodent Models of Human Narcolepsy-cataplexy

      • Takeshi Sakurai, Masashi Yanagisawa, Michihiro Mieda
      Pages 27-38

    3. The Canine Model of Narcolepsy

      • Seiji Nishino
      Pages 39-58

  4. Detailed Anatomy of the Hypocretinergic System and Related Hypothalamic Circuits

    1. Front Matter

      Pages 59-59
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    2. Anatomy of the Hypocretin System

      • Teresa L. Steininger, Thomas S. Kilduff
      Pages 61-75

    3. The Anatomy of Hypocretin Neurons

      • Tamas L. Horvath
      Pages 77-93

    4. Transmitter-Identified Neurons and Afferent Innervation of the Lateral Hypothalamic Area

      • Christian Broberger, Tomas Hökfelt
      Pages 95-120

  5. Physiological Consequences of Hypocretin Activation

    1. Front Matter

      Pages 121-121
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    2. Physiological Characteristics of Hypocretin/Orexin Neurons

      • Anthony N. van den Pol
      Pages 123-136

    3. The Ne System as a Target for Hypocretin Neurons

      • Gary Aston-Jones, J. Patrick Card, Yan Zhu, Mónica González, Elizabeth Haggerty
      Pages 137-152

    4. Hypocretin/Orexin Actions on Mesopontine Cholinergic Systems Controling Behavioral State

      • Christopher S. Leonard, Christopher J. Tyler, Sophie Burlet, Shigeo Watanabe, Kristi A. Kohlmeier
      Pages 153-168

    5. The Aminergic Systems and the Hypocretins

      • Oliver Selbach, Helmut L. Haas
      Pages 169-189

    6. Effects Of Hypocretin/Orexin on the Thalamocortical Activating System

      • Evelyn K. Lambe, George K. Aghajanian
      Pages 191-202

  6. Pharmacology of the Hypocretins and Drug Design

    1. Front Matter

      Pages 203-203
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    2. In Vivo Pharmacology of Orexin (Hypocretin) Receptors

      • Neil Upton
      Pages 205-220

    3. Intracellular Signal Pathways Utilized by the Hypocretin/Orexin Receptors

      • Jyrki P. Kukkonen, Karl E. O. Åkerman
      Pages 221-231
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Keywords

About this book

The first report that rapid eye movements occur in sleep in humans was published in 1953. The research journey from this point to the realization that sleep consists of two entirely independent states of being (eventually labeled REM sleep and non-REM sleep) was convoluted, but by 1960 the fundamental duality of sleep was well established including the description of REM sleep in cats associated with “wide awake” EEG patterns and EMG suppression. The first report linking REM sleep to a pathology occurred in 1961 and a clear association of sleep onset REM periods, cataplexy, hypnagogic hallucinations and sleep paralysis was fully established by 1966. When a naïve individual happens to observe a full-blown cataplexy attack, it is both dramatic and unnerving. Usually the observer assumes that the loss of muscle tone represents syncope or seizure. In order to educate health professionals and the general public, Christian Guilleminault and I made movies of full-blown cataplectic episodes (not an easy task). We showed these movies of cataplexy attacks to a number of professional audiences, and were eventually rewarded with the report of a similar abrupt loss of muscle tone in a dog. We were able to bring the dog to Stanford University and with this as the trigger, we were able to develop the Stanford Canine Narcolepsy Colony. Breeding studies revealed the genetic determinants of canine narcolepsy, an autosomal recessive gene we termed canarc1. Emmanuel Mignot took over the colony in 1986 and began sequencing DNA, finally isolating canarc1 in 1999.

Editors and Affiliations

  • The Scripps Research Institute, La Jolla, USA

    Luis Lecea, J. Gregor Sutcliffe

Bibliographic Information

  • Book Title: Hypocretins

  • Book Subtitle: Integrators of Physiological Signals

  • Editors: Luis Lecea, J. Gregor Sutcliffe

  • DOI: https://doi.org/10.1007/b107412

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag US 2005

  • Hardcover ISBN: 978-0-387-25000-7Published: 29 September 2005

  • Softcover ISBN: 978-1-4614-9806-3Published: 27 November 2014

  • eBook ISBN: 978-0-387-25446-3Published: 25 April 2007

  • Edition Number: 1

  • Number of Pages: XXIV, 441

  • Topics: Neurosciences, Endocrinology, Neurology

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