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Amyloid Protein Precursor in Development, Aging and Alzheimer’s Disease

  • Conference proceedings
  • © 1994

Overview

Editors:
  1. C. L. Masters

    1. Department of Pathology, The University of Melbourne and The Mental Health Research Institute of Victoria, Parkville, Australia

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  2. K. Beyreuther

    1. Center for Molecular Biology, University of Heidelberg, Heidelberg, Germany

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  3. M. Trillet

    1. Hôpital Neurologique, Lyon, France

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  4. Y. Christen

    1. Fondation IPSEN, Paris, France

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Part of the book series: Research and Perspectives in Alzheimer's Disease (ALZHEIMER)

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Table of contents (22 papers)

  1. Front Matter

    Pages I-XX
    Download chapter PDF

  2. Strategic Thoughts on the Alzheimer’s Disease Amyloid Protein Precursor: The Way Forward

    • C. L. Masters, K. Beyreuther
    Pages 1-8

  3. Drosophila Appl Gene and APPL Protein: A Model System to Study the Function of the APP Protein Family

    • K. White, L. Luo, T. Aigaki, M. Monastirioti
    Pages 9-20

  4. Amyloid βA4 of Alzheimer’s Disease: Structural Requirements for Folding and Aggregation

    • C. Hilbich, B. Kisters-Woike, C. L. Masters, K. Beyreuther
    Pages 21-35

  5. Production of Amyloid β Protein from Normal and Mutated Amyloid β Protein Precursors

    • T. E. Golde, X.-D. Cai, T.-T. Cheung, M. Shoji, S. G. Younkin
    Pages 36-45

  6. Mechanism of Cerebral Amyloidosis in Alzheimer’s Disease

    • D. Allsop, A. Clements, H. Kennedy, D. Walsh, C. Williams
    Pages 46-59

  7. Effects of Fragments of the ²-Amyloid Protein on Hippocampal Neurons in Young and Aged Rats: An Electrophysiological Study

    • B. Potier, P. Dutar, Y. Lamour
    Pages 60-64

  8. The Role of the Extracellular Matrix in Regulating the Function of the Amyloid Protein Precursor of Alzheimer’s Disease

    • D. H. Small, V. Nurcombe, G. Reed, H. Clarris, K. Beyreuther, C. L. Masters
    Pages 65-75

  9. Studies of the Amyloid Precursor Protein (APP) in Brain: Regulation of APP-Ligand Binding

    • G. Multhaup
    Pages 76-89

  10. The Biological Function of Amyloid β/A4 Protein Precursor

    • T. Saitoh, J.-M. Roch, L.-W. Jin, H. Ninomiya, D. A. C. Otero, K. Yamamoto et al.
    Pages 90-99

  11. Processing of Alzheimer Aβ-Amyloid Precursor Protein: Cell Biology, Regulation, and Role in Alzheimer’s Disease

    • S. Gandy, P. Greengard
    Pages 100-120

  12. Studies of APP Biology: Analysis of APP Secretion and Characterization of an APP Homologue, APLP2

    • S. S. Sisodia, H. H. Slunt, C. Van Koch, A. C. Y. Lo, G. Thinakaran
    Pages 121-133

  13. Transmembrane APP is Distributed into Two Pools and Associated with Polymerized Cytoskeleton

    • B. Allinquant, K. L. Moya, C. Bouillot, A. Prochiantz
    Pages 134-138

  14. Isolation and Characterisation of Novel Metalloproteases from Embryonic Mouse Hippocampus

    • A. Thorpe, V. Samtani, A. Gittner, W. Mills, S.-J. Richards
    Pages 139-143

  15. A Transgenic Mouse Model of Alzheimer’s Disease

    • B. Cordell, L. Higgins
    Pages 144-155

  16. Amyloid in Alzheimer’s Disease and Animal Models

    • D. L. Price, B. T. Lamb, J. D. Gearhart, L. J. Martin, L. C. Walker, E. H. Koo et al.
    Pages 156-168

  17. The Roles of Zinc and Copper in the Function and Metabolism of the Amyloid Protein Precursor Superfamily

    • A. I. Bush, W. Pettingell, R. E. Tanzi
    Pages 169-180

  18. The Diverse Molecular Nature of Inherited Alzheimer’s Disease

    • R. E. Tanzi, D. Romano, S. Gaston, A. Crowley, A. I. Bush, J. Peppercorn et al.
    Pages 181-189

  19. Genetic Variability and Alzheimer’s Disease

    • J. Hardy, M. Mullan, F. Crawford, K. Duff, R. Crook, P. Diaz et al.
    Pages 190-198

  20. Genetic Defects in Early Onset Alzheimer’s Disease and Related Disorders

    • L. Hendriks, C. Van Broeckhoven, the Alzheimer’s Disease Research Group
    Pages 199-208
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Keywords

Editors and Affiliations

  • Department of Pathology, The University of Melbourne and The Mental Health Research Institute of Victoria, Parkville, Australia

    C. L. Masters

  • Center for Molecular Biology, University of Heidelberg, Heidelberg, Germany

    K. Beyreuther

  • Hôpital Neurologique, Lyon, France

    M. Trillet

  • Fondation IPSEN, Paris, France

    Y. Christen

Bibliographic Information

  • Book Title: Amyloid Protein Precursor in Development, Aging and Alzheimer’s Disease

  • Editors: C. L. Masters, K. Beyreuther, M. Trillet, Y. Christen

  • Series Title: Research and Perspectives in Alzheimer's Disease

  • DOI: https://doi.org/10.1007/978-3-662-01135-5

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1994

  • Softcover ISBN: 978-3-662-01137-9Published: 29 August 2012

  • eBook ISBN: 978-3-662-01135-5Published: 17 April 2013

  • Series ISSN: 0945-6066

  • Series E-ISSN: 2196-310X

  • Edition Number: 1

  • Number of Pages: XX, 257

  • Number of Illustrations: 34 b/w illustrations, 10 illustrations in colour

  • Topics: Molecular Medicine, Internal Medicine

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