Overview
- Editors:
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Kleanthis G. Xanthopoulos
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NHGRI, National Institutes of Health, Bethesda, USA
Aurora Biosciences Inc., San Diego, USA
- A comprehensive treatise of molecular and clinical aspects of gene therapy
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Table of contents (22 papers)
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Front Matter
Pages I-VIII
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- Minoru Tomizawa, Julie Lekstrom-Himes, Kleanthis G. Xanthopoulos
Pages 17-36
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- Anthony Wynshaw-Boris, Carrolee Barlow, Amy Chen, Michael Gambello, Lisa Garrett, Theresa Hernandez et al.
Pages 37-44
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- Delphine Bohl, Jean-Michel Heard
Pages 53-59
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- Kelvin Davies, Ganjam Kalpana
Pages 71-76
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- Pierre Rodrigues, Jean-Michel Heard
Pages 77-82
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- Luz Marina Restrepo, Michel Masset, Jan Bayer, Liliane dal Cortivo, Jean Pierre Marolleau, Marc Benbunan et al.
Pages 83-90
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- Eric B. Kmiec, Allyson Cole-Strauss, Michael C. Rice, Pamela Havre
Pages 111-118
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- Giuliana Ferrari, Fulvio Mavilio
Pages 119-132
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- Susan A. Zullo, Natasha J. Caplen, R. Michael Blaese
Pages 133-145
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- N. Dumey, M. Masset, P. Devauchelle, M. Marty, O. Cohen-Haguenauer
Pages 147-156
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- Patrick Aebischer, Diego Braguglia
Pages 157-165
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- Christoph Uherek, Jesús Fominaya, Winfried Wels
Pages 167-170
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- S. Michael Rothenberg, Joan Fisher, David Zapol, David Anderson, Yasumichi Hitoshi, Philip Achacoso et al.
Pages 171-183
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About this book
Gene therapy has generated enormous expectations as it holds a great promise, namely to revolutionize clinical and molecular medicine. This is because the successful introduction of a gene sequence in somatic sells followed by long-term expression at therapeutic levels can fundamentally correct a variety of human disease such as inherited and acquired disorders, cancer and AIDS. The proceedings of the first ASI on Gene Therapy that took place from August 17-28, 1997 on the island of Spetsai, Greece, summarizes recent advances in the field as presented elegantly by the intemationally recognized experts that served as faculty at the meeting. Their contributions constitute brief but comprehensive reviews presented as independent chapters in this book and emphasize the influence of chromatin structure on gene expression, describe the principal mechanisms of gene expression, followed by articles on epigenic elements, viral vectors, non-viral vectors as gene delivery systems, animal models of human diseases, inducible regulatory systems, gene therapy of cancer, AIDS, monogenic disorders and ongoing clinical trials. Gene therapy is the logical progression to human health management because it offers a potential low cost and efficient treatment. Gene therapy can reach it's full potential and satisfy all expectations. However, a number of critical technology advancements need to be completed. These include the development of vectors capable of safe and efficient gene transfer, the control of cell type targeting and regulation of trans gene expression levels.
