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  • Book
  • © 2012

Molecular Aspects of Hematologic Malignancies

Diagnostic Tools and Clinical Applications

  • Up-to-date information on the molecular basis of selected hematologic disorders
  • Practical reference for molecular laboratory procedures
  • Of interest to clinical oncologists and hematologists as well as to graduates in molecular medicine, human genetics and laboratory medicine
  • Includes supplementary material: sn.pub/extras

Part of the book series: Principles and Practice (PRINCIPLES)

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Table of contents (29 chapters)

  1. Front Matter

    Pages i-x
  2. Molecular Biology of Selected Hemato-oncologic Diseases

    1. Front Matter

      Pages 1-1
    2. Molecular Biology of Acute Lymphoblastic Leukemia

      • Małgorzata Dawidowska, Monika D. Kraszewska, Katarzyna Derwich, Tomasz Szczepański
      Pages 3-28
    3. Genetic Mechanisms and Molecular Markers of Neoplastic Transformation in Acute Myeloid Leukemia

      • Agata A. Filip, Marta Libura, Sebastian Giebel, Olga Haus
      Pages 29-53
    4. Molecular Pathogenesis of Aggressive B-cell Lymphomas

      • Przemysław Juszczyński, Krzysztof Warzocha
      Pages 55-70
    5. Molecular Biology and Classification of Multiple Myeloma

      • Anna Dmoszyńska, Norbert Grząśko
      Pages 71-84
    6. Chronic Lymphocytic Leukemia

      • Anton W. Langerak, Yorick Sandberg
      Pages 85-101
    7. Molecular Biology of Chronic Myeloid Leukemia

      • Tomasz Sacha, Kajetana Foryciarz, Aleksander B. Skotnicki
      Pages 103-115
    8. Molecular Biology of Myelodysplastic Syndromes

      • Francesc Solé
      Pages 117-127
    9. Myeloproliferative Neoplasms

      • Andrzej Hellmann, Maria Bieniaszewska, Witold Prejzner, Aleksandra Leszczyńska
      Pages 129-140
  3. Diagnostics and Monitoring of Therapy of Hemato-oncologic Diseases

    1. Front Matter

      Pages 141-141
  4. Diagnostics and Monitoring of Therapy of Hemato-oncologic Deseases

    1. Flow Cytometric Immunophenotyping as Diagnostic Tool of Hematopoietic Malignancies

      • Łukasz Sędek, Juan Flores-Montero, Joanna Bulsa, Susana Barrena, Julia Almeida, Alberto Orfao et al.
      Pages 143-160
    2. Cytogenetics in Hematology

      • Olga Haus, Anna Poluha, Katarzyna Skonieczka
      Pages 161-181
    3. Monitoring of Minimal Residual Disease in Acute Lymphoblastic Leukemia

      • Tomasz Szczepański, Małgorzata Dawidowska, Katarzyna Derwich
      Pages 183-197
    4. Gene Expression Profiling in Hematologic Malignancies

      • Przemysław Juszczyński, Bjoern Chapuy, Małgorzata Szczepaniak, Krzysztof Warzocha
      Pages 199-214
  5. Molecular Procedures Involved in Hematopoietic Stem Cell Transplantation

    1. Front Matter

      Pages 215-215
    2. Chimerism Following Allogeneic Transplantation of Hematopoietic Stem Cells

      • Małgorzata Dawidowska, Katarzyna Guz, Ewa Brojer, Jacek Wachowiak, Michał Witt
      Pages 255-273
    3. Peritransplantation Monitoring of Minimal Residual Disease in Acute Lymphoblastic Leukemia

      • Małgorzata Dawidowska, Katarzyna Derwich, Tomasz Szczepański
      Pages 275-284

About this book

This book provides a state-of-the-art approach to the molecular basis of hematologic diseases and its translation into improved diagnostics and novel therapeutic strategies. Several representative hemato-oncologic malignancies are analyzed in detail: acute lymphoblastic leukemia, acute myeloid leukemia, B-cell Non-Hodgkin lymphomas, multiple myeloma, chronic lymphocytic leukemia, chronic myeloid leukemia, myelodysplastic syndromes, and myeloproliferative neoplasms. Experts in the field describe the molecular methods applied for modern diagnostics and therapies, such as hematopoietic stem cell transplantation, donor recipient matching, banking of biological material, analyses of post-transplant chimerism, and minimal residual disease monitoring. The volume concludes with an extensive section comprising thorough step-by-step protocols of molecular techniques in hematology, all of them validated in the authors’ own laboratories.

Reviews

From the reviews:

“This book describes current diagnostic tools and clinical procedures used for hematological malignancies. … The goal was to meet the needs of both clinical hematologists who treat patients with leukemia, lymphoma, and/or multiple myeloma and those who study these diseases in the laboratory. … an excellent review of molecular biology for specific hematological malignancies and disorders. It also covers important molecular testing techniques that are commonly used in the diagnosis, management, and surveillance of these malignancies. … a valuable addition to any hematologist’s library.” (John Patrick Galvin, Doody’s Review Service, October, 2012)

Editors and Affiliations

  • International Institute of Molecular and, Warszawa, Poland

    Michal Witt

  • , Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland

    Malgorzata Dawidowska

  • , Department of Pediatric Hematology, Silesian Academy of Medicine, Zabrze, Poland

    Tomasz Szczepanski

Bibliographic Information

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access