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Biomedical Sciences - Molecular Medicine | Alzheimer's Disease and Frontotemporal Dementia - Methods and Protocols

Alzheimer's Disease and Frontotemporal Dementia

Methods and Protocols

Series: Methods in Molecular Biology, Vol. 670

Roberson, Erik D. (Ed.)

2011, X, 270p.

A product of Humana Press
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  • -Supplies easily accessible techniques for the complex and wide-ranging avenues of AD and FTD research -Features invaluable descriptions of the experience of experts in the field to aid in the successful completion of experiments -Examines the diversity of the field today in a practical, lab-ready manner
Alzheimer’s disease and frontotemporal dementia, two of the most prevalent neurodegenerative diseases, are dreaded disorders that attack the neural networks underlying memory and personality, systems that make us who we are. Major breakthroughs in recent years have spurred new research approaches to these conditions. In Alzheimer's Disease and Frontotemporal Dementia: Methods and Protocols, expert investigators bring together the many divergent areas of expertise used to study these diseases, including behavior, electrophysiology, confocal microscopy, and hardcore biochemistry. Beginning with an overview of the two diseases and contemporary research on them, the book continues with specialized protocols for working with amyloid-β peptide, tau, and apolipoprotein E as well as experimental systems for studying AD and FTD, including cell and animal models, and outcome measures that can be used to assess neuronal function in these systems. Written in the highly successful Methods in Molecular Biology™ series format, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, Alzheimer's Disease and Frontotemporal Dementia: Methods and Protocols serves as an ideal guide for all scientists pursuing the cause and cure of these widespread and nightmarishly debilitating disorders.

Content Level » Professional/practitioner

Keywords » Amyloid-β peptide & apolipoprotein E - Cell and animal models - Genetic risk factors - Molecular neuropathology - Neurodegenerative disorder - Neuronal dysfunction - Pathobiochemistry

Related subjects » Molecular Medicine - Neurology

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