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Molecular Biology of the Parathyroid

  • Book
  • © 2005

Overview

Authors:
  1. Tally Naveh-Many

    1. Minerva Center for Calcium and Bone Metabolism Nephrology Services, Hadassah Hebrew University Medical Center, Jerusalem, Israel

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  • Molecular Biology of the Parathyroid is the first book to describe recent studies and discoveries in the field in detail.
  • This title is essention reading for enocrinologists and all researchers working in the field of bone and mineral research.
  • Includes supplementary material: sn.pub/extras

Part of the book series: Molecular Biology Intelligence Unit (MBIU)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xiv
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  2. Development of Parathyroid Glands

    • Thomas Günther, Gerard Karsenty
    Pages 1-7

  3. Parathyroid Hormone, from Gene to Protein

    • Osnat Bell, Justin Silver, Tally Naveh-Many
    Pages 8-28

  4. Toward an Understanding of Human Parathyroid Hormone Structure and Function

    • Lei Jin, Armen H. Tashjian Jr., Faming Zhang
    Pages 29-43

  5. The Calcium Sensing Receptor

    • Shozo Yano, Edward M. Brown
    Pages 44-56

  6. Regulation of Parathyroid Hormone mRNA Stability by Calcium and Phosphate

    • Rachel Kilav, Justin Silver, Tally Naveh-Many
    Pages 57-67

  7. In Silico Analysis of Regulatory Sequences in the Human Parathyroid Hormone Gene

    • Alexander Kel, Maurice Scheer, Hubert Mayer
    Pages 68-83

  8. Regulation of Parathyroid Hormone Gene Expression by 1,25-Dihydroxyvitamin D

    • Tally Naveh-Many, Justin Silver
    Pages 84-94

  9. Vitamin D Analogs for the Treatment of Secondary Hyperparathyroidism in Chronic Renal Failure

    • Alex J. Brown
    Pages 95-112

  10. Parathyroid Gland Hyperplasia in Renal Failure

    • Adriana S. Dusso, Mario Cozzolino, Eduardo Slatopolsky
    Pages 113-127

  11. Molecular Mechanisms in Parathyroid Tumorigenesis

    • Eitan Friedman
    Pages 128-139

  12. Molecular Genetic Abnormalities in Sporadic Hyperparathyroidism

    • Trisha M. Shattuck, Sanjay M. Mallya, Andrew Arnold
    Pages 140-158

  13. Genetic Causes of Hypoparathyroidism

    • Rachel I. Gafni, Michael A. Levine
    Pages 159-178

  14. Skeletal and Reproductive Abnormalities in Pth-Null Mice

    • Dengshun Miao, Bin He, Beate Lanske, Xiu-Ying Bai, Xin-Kang Tong, Geoffrey N. Hendy et al.
    Pages 179-196

  15. Back Matter

    Pages 197-199
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Keywords

About this book

aintaining extracellular calcium concentrations within a narrow range is critical for the survival of most vertebrates. PTH, together with vitamin D, responds to hypocalcemia to increase extracellu­ M lar calcium levels, by acting on bone, kidney and intestine. The recent intro­ duction of PTH as a major therapeutic agent in osteoporosis has directed renewed interest in this important hormone and in the physiology of the parathyroid gland. The parathyroid is unique in that low serum calcium stimulates PTH secretion. As hypocalcemia persists, there is also an increase in PTH synthesis. Chronic hypocalcemia leads to hypertrophy and hyper­ plasia of the parathyroid gland together with increased production of the hormone. Phosphate is also a key modulator of PTH secretion, gene expres­ sion and parathyroid cell proliferation. Understanding the biology of the parathyroid as well as the mecha­ nisms of associated diseases has taken great strides in recent years. This book summarizes the molecular mechanisms involved in the function of the para­ thyroid gland. The first chapter reviews the development of the parathyroid gland and the genes involved in this process as identified using genetically manipulated mice. Then the biosynthetic pathway of PTH from gene ex­ pression to its intracellular processing and the sequences in the gene control­ ling its transcription as well as those regulating mRNA processing, stability and translation are described.

Authors and Affiliations

  • Minerva Center for Calcium and Bone Metabolism Nephrology Services, Hadassah Hebrew University Medical Center, Jerusalem, Israel

    Tally Naveh-Many

Bibliographic Information

  • Book Title: Molecular Biology of the Parathyroid

  • Authors: Tally Naveh-Many

  • Series Title: Molecular Biology Intelligence Unit

  • DOI: https://doi.org/10.1007/0-387-27530-4

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag US 2005

  • Hardcover ISBN: 978-0-306-47847-5Published: 01 February 2005

  • Softcover ISBN: 978-1-4419-3415-4Published: 06 December 2010

  • eBook ISBN: 978-0-387-27530-7Published: 26 February 2007

  • Series ISSN: 1431-0414

  • Edition Number: 1

  • Number of Pages: XIV, 199

  • Number of Illustrations: 66 b/w illustrations, 5 illustrations in colour

  • Additional Information: Jointly published with Landes Bioscience, Austin, TX, USA

  • Topics: Molecular Medicine, Nephrology, Endocrinology

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