Proteins and Proteomics of Leishmania and Trypanosoma

1. Front Matter

   Pages i-x

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2. Biology of Human Pathogenic Trypanosomatids: Epidemiology, Lifecycle and Ultrastructure

   • Juliany Cola Fernandes Rodrigues, Joseane Lima Prado Godinho, Wanderley de Souza

   Pages 1-42

3. Selection of Molecular Targets for Drug Development Against Trypanosomatids

   • Despina Smirlis, Milena Botelho Pereira Soares

   Pages 43-76

4. A2 and Other Visceralizing Proteins of Leishmania: Role in Pathogenesis and Application for Vaccine Development

   • Ana Paula Fernandes, Adriana Monte Cassiano Canavaci, Laura-Isobel McCall, Greg Matlashewski

   Pages 77-101

5. Arginase in Leishmania

   • Maria Fernanda Laranjeira da Silva, Lucile Maria Floeter-Winter

   Pages 103-117

6. The Heat Shock Proteins of Trypanosoma cruzi

   • Turán P. Ürményi, Rosane Silva, Edson Rondinelli

   Pages 119-135

7. The gp82 Surface Molecule of Trypanosoma cruzi Metacyclic Forms

   • Cristian Cortez, Tiago J. P. Sobreira, Fernando Y. Maeda, Nobuko Yoshida

   Pages 137-150

8. The Gp85 Surface Glycoproteins from Trypanosoma cruzi

   • Eliciane C. Mattos, Renata R. Tonelli, Walter Colli, Maria Julia M. Alves

   Pages 151-180

9. Trypanosoma cruzi Trans-Sialidase: Structural Features and Biological Implications

   • Isadora A. Oliveira, Leonardo Freire-de-Lima, Luciana L. Penha, Wagner B. Dias, Adriane R. Todeschini

   Pages 181-201

10. Surface Topology Evolution of Trypanosoma Trans-Sialidase

    • Sergio Steven Cornejo Rubin De Celis

    Pages 203-216

11. Ecto-nucleotidases and Ecto-phosphatases from Leishmania and Trypanosoma Parasites

    • Anita Leocadio Freitas-Mesquita, José Roberto Meyer-Fernandes

    Pages 217-252

12. GP63 Function in the Interaction of Trypanosomatids with the Invertebrate Host: Facts and Prospects

    • Claudia M. d’Avila-Levy, Ellen C. F. Altoé, Lívia A. Uehara, Marta H. Branquinha, André L. S. Santos

    Pages 253-270

13. Highlights on Trypanosomatid Aminoacyl-tRNA Synthesis

    • Carla Polycarpo

    Pages 271-304

14. The Expected Outcome of the Trypanosoma cruzi Proteomic Map: A Review of Its Potential Biological Applications for Drug Target Discovery

    • Rubem F. S. Menna-Barreto, Jonas Perales

    Pages 305-322

15. Proteomics Advances in the Study of Leishmania Parasites and Leishmaniasis

    • Jose Batista de Jesus, Camila Mesquita-Rodrigues, Patricia Cuervo

    Pages 323-349

16. Towards the Phosphoproteome of Trypanosomatids

    • Fabricio K. Marchini, Lyris Martins Franco de Godoy, Michel Batista, Fernanda G. Kugeratski, Marco A. Krieger

    Pages 351-378

17. Back Matter

    Pages 379-381

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This book contains a collection of critical reviews on the expression of biologically functional proteins in Leishmania and Trypanosoma, which was written by renowned researchers on this field. Species belonging to these trypanosomatids’ genera are etiological agents of leishmaniasis, Chagas’ disease and sleeping sickness that are extremely debilitating human infection diseases, which remain a major health problem especially in countries from Latin America, Africa and Middle East. Substantiating the problem, the currently accepted drugs for these diseases are quiet unsatisfying due to their low efficacy and high toxicity. In order to solve these real problems, several research groups around the world have become involved in the study and identification of novel potential targets in the trypanosomatid cell. Since proteins are key macromolecules involved in crucial metabolic processes of all living cells, studies have focused on the expression of specific proteins produced by Leishmania and Trypanosoma by means of different biochemical, molecular and proteomic approaches in order to explore them as targets for understanding the parasite life cycle and developing new strategies against trypanosomiasis. With these proposals in mind, the book “Proteins and Proteomics of Leishmania and Trypanosoma” encompasses (i) an integrated view about the biochemistry of parasites belonging to the Leishmania and Trypanosoma genera; (ii) an updated review on the expression of biologically relevant proteins by human pathogenic trypanosomatids and their possible role in the interaction with host cells/molecules as well as a target for development of both alternative chemotherapies and vaccine; and (iii) several pictures, diagrams and tables that can be used to illustrate both undergraduate and postgraduate teaching as well as scientific lectures, being a useful resource for students andresearchers.

• Chemotherapy
• Leishmania
• Protein
• Proteomic
• Trypanosoma
• infectious diseases

From the book reviews:

“This is an updated review of the current understanding of the molecular, cellular biology, and biochemistry aspects, including protein expression and functions of the two protozoan parasitic genera, Leishmania and Trypanosoma. … this is a good book for both undergraduate and postgraduate students as well as researchers in the field. … This is a well-organized book outlining the current understanding of the biology and biochemistry of two important parasitic agents.” (Vaibhav Tiwari, Doody’s Book Reviews, January, 2015)

• Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

  André L.S. Santos

• Departamento de Microbiologia Geral, Ins. de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

  Marta H. Branquinha

• Fundação Oswaldo Cruz, Rio de Janeiro, Brazil

  Claudia M. d’Avila-Levy, Lucimar F. Kneipp

• Departamento de Biologia Celular e Molecular, Instituto de Biologia Universidade Federal Fluminense, Niterói, Brazil

  Cátia L. Sodré

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