Molecular Parasitology

1. Front Matter

   Pages i-ix

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2. The Molecules

   1. Front Matter

      Pages 1-1

      PDF

   2. Genomics

      • Omar S. Harb, Ulrike Boehme, Kathryn Crouch, Olukemi O. Ifeonu, David S. Roos, Joana C. Silva et al.

      Pages 3-48

   3. Proteomics

      • Jonathan Wastling, Dong Xia

      Pages 49-74

   4. Glycomics

      • Iain B. H. Wilson

      Pages 75-89

3. The Parasites (and Their Molecules)

   1. Front Matter

      Pages 91-91

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   2. Giardia

      • Norbert Müller, Joachim Müller

      Pages 93-114

   3. Trichomonas

      • Pier Luigi Fiori, Paola Rappelli, Daniele Dessì, Robert Hirt, Sven Gould, Jan Tachezy et al.

      Pages 115-155

   4. Trypanosoma

      • Christine Clayton

      Pages 157-194

   5. Leishmania

      • Anton Aebischer, Martin Mrva

      Pages 195-216

   6. Toxoplasma

      • Carsten G. K. Lüder, Frank Seeber

      Pages 217-239

   7. Plasmodium

      • Volker Heussler, Tobias Spielmann, Friedrich Frischknecht, Tim Gilberger

      Pages 241-284

   8. Acanthamoeba

      • Martina Köhsler, Martin Mrva, Julia Walochnik

      Pages 285-324

   9. Entamoeba

      • Michael Duchêne

      Pages 325-379

4. Hot Topics

   1. Front Matter

      Pages 381-381

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   2. Phylogeny and Evolution

      • Christen M. Klinger, Anna Karnkowska, Emily K. Herman, Vladimir Hampl, Joel B. Dacks

      Pages 383-408

   3. Host-Parasite Interactions

      • Heinrich Körner, Shanshan Hu, Christian Bogdan

      Pages 409-430

   4. Parasite-Vector Interactions

      • Günter A. Schaub, Patric Vogel, Carsten Balczun

      Pages 431-489

   5. From Molecule to Drug

      • Pascal Mäser, Reto Brun

      Pages 491-507

   6. Vaccine Development

      • Julie Healer, Alan F. Cowman

      Pages 509-525

In the past years, genome projects for numerous human parasites have been completed and now allow first in depth comparisons and evolutionary conclusions. The genomes of parasites reflect the coevolution with their host, metabolic capacities depending on their respective habitat in the host. Gut parasites usually have an anaerobic metabolism, while blood parasites have an aerobic metabolism, intracellular parasites escape the immune system, while extracellular parasites evade the immune system, usually by antigenic variation. Comprehensive genome data now being available allow us to address profound scientific questions, such as which traits enable the parasite to survive in the human host, which to cause disease and which can be used as drug targets. This book intends to give an overview of the state of knowledge on “the molecules” of protozoan parasites – on their genomes, proteomes, glycomes and lipidomes.

• Trypanosoma
• Tropical Medicine
• Leishmania
• Host parasite co-evolution
• drug design

• Institute of Specific Prophylaxis and Tropical Medicine, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria

  Julia Walochnik

• Institute of Specific Prophylaxis and Tropical Medicine, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna , Vienna, Austria

  Michael Duchêne

Julia Walochnik and Michael Duchêne are associate professors at the Institute of Specific Prophylaxis and Tropical Medicine in the Center for Pathophysiology, Infectiology and Immunology of the Medical University of Vienna. Julia Walochnik´s work is focused on the molecular biology of Acanthamoeba spp. and other protozoan parasites. Together with her group she has published more than 130 scientific publications, including book chapters and reviews. Michael Duchêne studies the biochemistry and molecular biology of Entamoeba histolytica. Further interests are allergens and antigenic structures of bacteria. Together with his students and collaborators, he has published more than 90 scientific publications plus several book chapters.  

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