Fills a void, as there is no encyclopedic collection on the topic
Topic is very timely, as instances of antimicrobial resistance increase and once-controllable diseases spread
While many volumes have been written about various aspects of antimicrobial resistance, this book is a comprehensive reference work. All manifestations of resistance are addressed: viral; bacterial, parasitical and fungal are given dedicated sections. The underlining molecular mechanisms, which depend not only on the microbe but on the specific drug (target), are highly diverse. This work discusses and compares the biological, biochemical and structural aspects of resistance and its evolution.
Bacteria.- Origins of antibiotic resistance (Resistome).- Dissemination of antibiotic resistance.- Mechanisms of antibiotic resistance.-Strategies for combating antibiotic resistance.- Multiple-drug-resistant bacteria.- Resistant Tuberculosis.- MRSA.- Fungi.- Microevolution of drug resistance.- Environmental induction of azole resistance in medical molds.- Echinocandin resistance in medically relevant fungi.-Role of drug efflux in azole resistance.- Parasites.- Drug-resistant Leishmania.- Drug resistance in Helminth infections.- Drug resistance in Malaria.- Drug resistance in schistosoma infections.- Drug resistance in trypanosome infections.- HIV.- Resistance to RT inhibitors.- Resistance to Integrase Inhibitors.- Resistance to Entry inhibitors.- Resistance Testing.- Virology.- Resistance to viral protease inhibitors: The substrate envelope.- Resistance to new Direct-Acting-Antivirals against HCV.- HBV Resistance.- Resistance to antiherpetic drugs.- Influenza Resistance.