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Pathogen Genomics

Impact on Human Health

  • Book
  • © 2002

Overview

Editors:
  1. Karen Joy Shaw

    1. Department of Infectious Diseases, Johnson and Johnson Pharmaceutical Research and Development, L. L. C., San Diego, USA

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Part of the book series: Infectious Disease (ID)

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xv
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  2. Viruses

    1. Front Matter

      Pages xvii-xvii
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    2. Antiviral Drug Target Discovery with DNA Microarrays

      • Klaus Früh, Peter Ghazal
      Pages 1-11

    3. Chipping Away at HIV Pathogenesis

      • Steffney Elise Rought, Roman Sasik, Davey Mitchell Smith, Jacques Corbeil
      Pages 13-24

    4. Microarray Analysis of Human Papillomavirus Pathogenesis

      • Yijan Elaine Chang, Laimonis A. Laimins
      Pages 25-38

    5. Ribozymes as Gene Therapeutic Agents for HIV/AIDS

      • Gregory C. Fanning, Janet L. Macpherson, Geoff Symonds
      Pages 39-51

  3. Bacteria

    1. Front Matter

      Pages N1-N1
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    2. Genomics and New Technologies Applied to Antibacterial Drug Discovery

      • Donald T. Moir
      Pages 53-68

    3. Genomics of the Mycobacterium tuberculosis Complex and BCG Vaccines

      • Marcel A. Behr, Stephen V. Gordon
      Pages 69-81

    4. Bacterial “Genes-to-Screens” in the Post-Genomic Era

      • Michael J. Pucci, John F. Barrett, Thomas J. Dougherty
      Pages 83-96

    5. DNA Microarray Expression Analysis in Antibacterial Drug Discovery

      • Brian J. Morrow, Karen Joy Shaw
      Pages 97-112

    6. The Influence of Genomics on the Molecular Epidemiology of Nosocomial Pathogens

      • Richard V. Goering
      Pages 113-131

    7. Borrelia Genomics as a Tool for Studying Pathogenesis and Vaccine Development

      • Alireza Shamaei-Tousi, Sven Bergström
      Pages 133-154

  4. Fungi

    1. Front Matter

      Pages N3-N3
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    2. Antifungal Target Discovery and Evaluation

      • Beth DiDomenico, Scott S. Walker
      Pages 155-166

    3. Antifungal Drug Discovery: Old Drugs, New Tools

      • Marianne D. De Backer, Walter H. M. L. Luyten, Hugo F. Vanden Bossche
      Pages 167-196

    4. Cryptococcus neoformans

      • Jennifer K. Lodge, John R. Perfect
      Pages 197-214

    5. Antifungal Target Selection in Aspergillus nidulans

      • Rosanna Pena-Muralla, Patricia Ayoubi, Marcia Graminha, Nilce M. Martinez-Rossi, Antonio Rossi, Rolf A. Prade
      Pages 215-230

    6. Functional Genomics of Histoplasma capsulatum

      • Glenmore Shearer Jr.
      Pages 231-245

    7. Gene-Finding in Coccidioides immitis

      • Theo N. Kirkland, Garry T. Cole
      Pages 247-254
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Keywords

About this book

Leading infectious disease researchers and pharmaceutical scientists comprehensively review the latest genomic technologies and their application to the prevention, diagnosis, and treatment. The authors' cross-disciplinary approach, with expertise acquired from studying disease-causing viruses, bacteria, fungi, and protozoa, reveals how sequence information from diverse pathogens has uncovered novel targets for drug discovery, antigenic determinants for vaccine development, as well as diagnostic tools. The authors also discuss the application of DNA micoarrays and the impact of genome sequencing comparisons on the discovery and choices of novel drug targets. The result is a better understanding how genomic information can reveal the fundamentals of microbial pathogenesis and how organisms interact with their host environment.

Reviews

"As a result of this comprehensive genomic information relying on new technologies and experimental tools, a novel quality in understanding pathogenicity has been reached. This is illustrated in the book in an impressive manner." -Proteomics

Editors and Affiliations

  • Department of Infectious Diseases, Johnson and Johnson Pharmaceutical Research and Development, L. L. C., San Diego, USA

    Karen Joy Shaw

Bibliographic Information

  • Book Title: Pathogen Genomics

  • Book Subtitle: Impact on Human Health

  • Editors: Karen Joy Shaw

  • Series Title: Infectious Disease

  • DOI: https://doi.org/10.1007/978-1-59259-172-5

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2002

  • Hardcover ISBN: 978-1-58829-026-7Published: 17 May 2002

  • Softcover ISBN: 978-1-4684-9683-3Published: 12 December 2012

  • eBook ISBN: 978-1-59259-172-5Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XVII, 309

  • Topics: Medical Microbiology, Infectious Diseases, Pharmacology/Toxicology

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