Astrovirus Research

1. Front Matter

   Pages i-xiv

   PDF

2. Epidemiology of Human Astroviruses

   • Albert Bosch, Susana Guix, Rosa M. Pintó

   Pages 1-18

3. Replication Cycle of Astroviruses

   • Ernesto Méndez, Andrea Murillo, Rodrigo Velázquez, Andrew Burnham, Carlos F. Arias

   Pages 19-45

4. Astrovirus Structure and Assembly

   • Rebecca M. Dubois, Kelly A. Dryden, Mark Yeager, Yizhi J. Tao

   Pages 47-64

5. Astrovirus Pathogenesis

   • Victoria Meliopoulos, Stacey Schultz-Cherry

   Pages 65-77

6. Immune Responses

   • Neel K. Krishna, Matthew D. Koci, Susana Guix

   Pages 79-95

7. Astrovirus Taxonomy

   • Susana Guix, Albert Bosch, Rosa M. Pintó

   Pages 97-118

8. New Human Astroviruses

   • Stacy R. Finkbeiner, Lori R. Holtz

   Pages 119-133

9. Astrovirus Infections in Animal Mammalian Species

   • Giovanni Cattoli, Daniel Ka Wing Chu, Malik Peiris

   Pages 135-149

10. Avian Astroviruses

    • Mary Pantin-Jackwood, Daniel Todd, Matthew D. Koci

    Pages 151-180

11. Back Matter

    Pages 181-185

    PDF

Astroviruses were first identified in the feces of children in 1975.  Since then, they have been found in ~ 3 to 20% of children with diarrhea.  Given that serological studies have demonstrated that up to 90% of children have been exposed to at least one strain of astrovirus by age 9, the prevalence of infection may be much higher.  Supporting this are studies demonstrating that astroviruses can also be isolated in a subset of asymptomatic individuals, suggesting that a proportion of infected individuals shed the virus asymptomatically or for some time after the resolution of other symptoms of infection.  Asymptomatic carriers may be a major reservoir for astroviruses in the environment and could contribute to dissemination of the virus.  Astroviruses are extremely stable in the environment and can be transmitted nosocomially, directly from infected individuals and potentially animals, and through contaminated food and water. Although typically an acute disease, astrovirus infection inpremature infants may be associated with the development of necrotizing enterocolitis and in new-onset celiac disease in children.  Immunocompromised children are even more susceptible often developing persistent infections that lead to wasting or even systemic infections associated with fatal encephalitis.   In spite of its importance, little is known about astrovirus pathogenesis, molecular biology, epidemiology, or cell biology.  The goal of this book is to provide the latest and most up-to-date information on this medically important and rapidly evolving group of viruses.  It will include sections on the history of astroviruses and their disease in humans; information on viral replication and immune responses; new information on how astroviruses induce disease including the expression of a viral enterotoxin regulating intestinal epithelial cell tight junctions, the isolation and identification of new astrovirus genotypes in mammals including humans, and astroviruses of veterinaryimportance.  Finally, the book will also introduce the complexity of astrovirus epidemiology and potential as an important new zoonotic disease, and its role in food-borne disease.  This will be the first book of its kind and will be of great interest to microbiologists, virologists, infectious disease specialists, immunologists, pediatricians, public health and food safety experts, veterinarians, poultry industry specialists, and researchers and clinicians interested in enteritis. ​

• astrovirus
• celiac disease
• epidemiology
• zoonotic
• infectious diseases

• , Infectious Diseases, St Jude Children’s Research Hospital, Memphis, USA

  Stacey Schultz-Cherry

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