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Poly(ADP-Ribosyl)ation

  • Book
  • © 2006

Overview

Authors:
  1. Alexander Bürkle

    1. Molecular Toxicology Group Department of Biology, University of Konstanz, Konstanz, Germany

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  • Poly(ADP-Ribosyl)ation, edited by Alexander Bürkle, provides the most comprehensive and up-to-date reference on this posttranslational modification of proteins, which is intimately linked with DNA repair, maintenance of genomic stability, transcriptional regulation, cell death and a variety of other cellular phenomena as well as with a variety of pathophysiological conditions, including ischemia-reperfusion damage (stroke, myocardial infarction), Parkinson’s disease, Type I diabetes mellitus, hemorrhagic and septic shock and other inflammatory conditions.
  • This book comprises 19 chapters written by leading international experts in the field and is richly illustrated.

Part of the book series: Molecular Biology Intelligence Unit (MBIU)

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-xvii
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  2. Enzymes in Poly(ADP-Ribose) Metabolism

    • Ralph G. Meyer, Mirella L. Meyer-Ficca, Elaine L. Jacobson, Myron K. Jacobson
    Pages 1-12

  3. PARP-2: Structure-Function Relationship

    • Valérie Schreiber, Michelle Ricoul, Jean-Christophe Amé, Françoise Dantzer, Véronique Meder, Catherine Spenlehauer et al.
    Pages 13-31

  4. Targeting the Poly (ADP-Ribose) Glycohydrolase (PARG) Gene in Mammals

    • Ulrich Cortes, Zhao-Qi Wang
    Pages 32-40

  5. DNA Damage Signaling through Poly(ADP-Ribose)

    • Maria Malanga, Felix R. Althaus
    Pages 41-50

  6. Roles of Poly(ADP-Ribose) Metabolism in the Regulation of Centrosome Duplication and in the Maintenance of Neuronal Integrity

    • Masanao Miwa, Masayuki Kanai, Masahiro Uchida, Kazuhiko Uchida, Shuji Hanai
    Pages 51-60

  7. Functional Interactions of PARP-1 with p53

    • Rafael Alvarez-Gonzalez, Hanswalter Zentgraf, Manfred Frey, Hilda Mendoza-Alvarez
    Pages 61-66

  8. Dynamic Interaction between PARP-1, PCNA and p21waf1/cip1

    • Ennio Prosperi, A. Ivana Scovassi
    Pages 67-74

  9. PARP-1 as Novel Coactivator of NF-κB in Inflammatory Disorders

    • Paul O. Hassa, Michael O. Hottiger
    Pages 75-90

  10. PARP and Epigenetic Regulation

    • Paola Caiafa
    Pages 91-102

  11. PARP and the Release of Apoptosis-Inducing Factor from Mitochondria

    • Suk Jin Hong, Ted M. Dawson, Valina L. Dawson
    Pages 103-117

  12. Genome Degradation by DNAS1L3 Endonuclease

    • A. Hamid Boulares, Alexander G. Yakovlev, Mark E. Smulson
    Pages 118-131

  13. NAD: Metabolism and Regulatory Functions

    • Mathias Ziegler
    Pages 132-140

  14. PARP-1 and the Shape of Cell Death

    • László Virág
    Pages 141-152

  15. Poly(ADP-Ribose) Polymerase (PARP) and Excitotoxicity

    • Domenico E. Pellegrini-Giampietro, Alberto Chiarugi, Flavio Moroni
    Pages 153-163

  16. Poly(ADP-Ribose) Polymerase and Ischemia-Reperfusion Injury

    • Prabal K. Chatterjee, Christoph Thiemermann
    Pages 164-183

  17. Role of Poly(ADP-Ribose) Polymerase Activation in the Pathogenesis of Inflammation and Circulatory Shock

    • Csaba Szabó
    Pages 184-202

  18. Role of Poly-ADP-Ribosylation in Cancer Development

    • Mitsuko Masutani, Akemi Gunji, Masahiro Tsutsumi, Kumiko Ogawa, Nobuo Kamada, Tomoyuki Shirai et al.
    Pages 203-217

  19. PARP Inhibitors and Cancer Therapy

    • Nicola J. Curtin
    Pages 218-233

  20. Poly(ADP-Ribosyl)ation and Aging

    • Sascha Beneke, Alexander Bürkle
    Pages 234-241
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About this book

Poly(ADP-Ribosyl)ation comprises 19 chapters written by leading international experts in the field and is richly illustrated. Extensive bibliography is given in each chapter.

Authors and Affiliations

  • Molecular Toxicology Group Department of Biology, University of Konstanz, Konstanz, Germany

    Alexander Bürkle

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