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Biomedical Sciences - Immunology | Thymic Development and Selection of T Lymphocytes

Thymic Development and Selection of T Lymphocytes

Boehm, Thomas, Takahama, Yousuke (Eds.)

2014, VII, 132 p. 11 illus., 9 illus. in color.

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  • Written by leading experts in the field
  • Addresses key aspects of the process of thymopoiesis
  • Offers perspectives for understanding immunodeficiency and autoimmune diseases
  •  

The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.

Content Level » Research

Keywords » Adaptive immunity - Autoimmunity - Cellular immunity - Immunodeficiency - Thymus function

Related subjects » Human Genetics - Human Physiology - Immunology

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