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Signal Transduction and the Coordination of B Lymphocyte Development and Function I

Transduction of BCR Signals from the Cell Membrane to the Nucleus

  • Book
  • © 2000

Overview

Editors:
  1. Louis B. Justement

    1. Division of Developmental & Clinical Immunology Department of Microbiology, University of Alabama at Birmingham, Birmingham, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Katherine A. Siminovitch

    1. Department of Medicine, University of Toronto Mount Sinai Hospital, Toronto, Canada

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 245/1)

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Table of contents (7 chapters)

  1. Front Matter

    Pages I-XV
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  2. Signal Transduction via the B-cell Antigen Receptor: The Role of Protein Tyrosine Kinases and Protein Tyrosine Phosphatases

    • Louis B. Justement
    Pages 1-51

  3. The B-Cell Antigen Receptor: Formation of Signaling Complexes and the Function of Adaptor Proteins

    • J. Wienands
    Pages 53-76

  4. Intermediary Signaling Effectors Coupling the B-Cell Receptor to the Nucleus

    • M. R. Gold
    Pages 77-134

  5. Involvement of the Lymphocyte Cytoskeleton in Antigen-Receptor Signaling

    • L. A. G. da Cruz, S. Penfold, J. Zhang, A.-K. Somani, F. Shi, M. K. H. McGavin et al.
    Pages 135-167

  6. Pax-5/BSAP: Regulator of Specific Gene Expression and Differentiation in B Lymphocytes

    • J. Hagman, W. Wheat, D. Fitzsimmons, W. Hodsdon, J. Negri, F. Dizon
    Pages 169-194

  7. Receptor Modulators of B-Cell Receptor Signalling — CD19/CD22

    • K. G. C. Smith, D. T. Fearon
    Pages 195-212

  8. Positive and Negative Signaling in B Lymphocytes

    • K. M. Coggeshall
    Pages 213-260

  9. Back Matter

    Pages 261-267
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Keywords

About this book

Proper development and differentiation of B lymphocytes is es­ sential to ensure that an organism has the ability to mount an effective humoral immune response against foreign antigens. The immune system must maintain a balance between the deletion of harmful self-reactive B cells and the generation of a diverse rep­ ertoire of B cells that has the ability to recognize an almost un­ limited array of foreign antigens. The need to delete self-reactive cells is tempered by the need to avoid the generation of large functional holes in the repertoire of foreign antigen-specific B cells that patrol the periphery. To accomplish this, the immune system must reach a compromise by eliminating only the most dangerous autoreactive clones, while allowing less harmful au­ toreactive B cells to exist in the periphery where they may com­ plement the organism's ability to mount a rapid response against invading micro-organisms. Those autoreactive cells that do enter the peripheral pool are subject to a number of conditional re­ straints that effectively attenuate their ability to respond to self­ antigens. Deleterious alterations in the homeostasis between tolerance induction and recruitment of B cells into the functional repertoire may lead to increased susceptibility to autoimmune disease or infection, respectively. Therefore, delineation of the molecular processes that maintain immunological homeostasis in the B cell compartment is critical.

Editors and Affiliations

  • Division of Developmental & Clinical Immunology Department of Microbiology, University of Alabama at Birmingham, Birmingham, USA

    Louis B. Justement

  • Department of Medicine, University of Toronto Mount Sinai Hospital, Toronto, Canada

    Katherine A. Siminovitch

Bibliographic Information

  • Book Title: Signal Transduction and the Coordination of B Lymphocyte Development and Function I

  • Book Subtitle: Transduction of BCR Signals from the Cell Membrane to the Nucleus

  • Editors: Louis B. Justement, Katherine A. Siminovitch

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-57066-7

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2000

  • Hardcover ISBN: 978-3-540-66002-6Published: 19 August 1999

  • Softcover ISBN: 978-3-642-63017-0Published: 23 October 2012

  • eBook ISBN: 978-3-642-57066-7Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: XV, 267

  • Topics: Immunology, Cell Biology, Molecular Medicine

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