Editors:
- Includes supplementary material: sn.pub/extras
Part of the book series: Ernst Schering Foundation Symposium Proceedings (SCHERING FOUND, volume 44)
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Table of contents (11 papers)
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Front Matter
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Back Matter
About this book
An essential component of inflammation is the migration of circulating leukocytes from blood into tissues. This process is characterized by a multistep paradigm of sequential cell adhesion and activation events that lead to the extravasation of specific leukocyte subsets to different tissues in health and disease. The first step of leukocyte extravasation, the rolling of leukocytes, is primarily mediated by the interactions of selectins and their ligands. It has recently become evident that fucosyltransferases are crucial for selectin ligand synthesis, inflammation, and skin homing. This book provides an in-depth overview of the mechanisms of leukocyte trafficking and of the molecular mechanisms of selectin/selectin ligand interactions and discusses options for pharmacological intervention to treat inflammatory diseases.
Editors and Affiliations
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Experimental Rheumatology, Medical Clinic, University Hospital Charité, Berlin, Germany
Alf Hamann
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Corporate Research Business, Area Dermatology, Schering AG, Berlin, Germany
Khusru Asadullah, Arndt Schottelius
Bibliographic Information
Book Title: Leucocyte Trafficking
Book Subtitle: The Role of Fucosyltransferases and Selectins
Editors: Alf Hamann, Khusru Asadullah, Arndt Schottelius
Series Title: Ernst Schering Foundation Symposium Proceedings
DOI: https://doi.org/10.1007/978-3-662-05397-3
Publisher: Springer Berlin, Heidelberg
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eBook Packages: Springer Book Archive
Copyright Information: Springer-Verlag Berlin Heidelberg 2004
Hardcover ISBN: 978-3-540-40112-4Published: 07 October 2003
Softcover ISBN: 978-3-662-05399-7Published: 03 October 2013
eBook ISBN: 978-3-662-05397-3Published: 29 June 2013
Series ISSN: 0947-6075
Edition Number: 1
Number of Pages: XIV, 242
Topics: Human Physiology, Immunology, Molecular Medicine, Dermatology