Editors:
- Written by leading experts in the field
- Provides a comprehensive and up to date overview of Fc receptors
- Covers aspects of Fc receptor-targeted therapies for the treatment of inflammation, cancer and other diseases
- Includes supplementary material: sn.pub/extras
Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 382)
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Table of contents (18 chapters)
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Front Matter
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FcR Biology
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Front Matter
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FcRs and Disease
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Front Matter
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About this book
This volume provides a state-of-the-art update on Fc Receptors (FcRs). It is divided into five parts. Part I, Old and New FcRs, deals with the long-sought-after FcµR and the recently discovered FCRL family and TRIM21. Part II, FcR Signaling, presents a computational model of FcεRI signaling, novel calcium channels, and the lipid phosphatase SHIP1. Part III, FcR Biology, addresses major physiological functions of FcRs, their glycosylation, how they induce and regulate both adaptive immune responses and inflammation, especially in vivo, FcR humanized mice, and the multifaceted properties of FcRn. Part IV, FcRs and Disease, discusses FcR polymorphism, FcRs in rheumatoid arthritis and whether their FcRs make macaques good models for studying HIV infection. In Part V, FcRs and Therapeutic Antibodies, the roles of various FcRs, including FcγRIIB and FcαRI, in the immunotherapy of cancer and autoimmune diseases using monoclonal antibodies and IVIg are highlighted. All 18 chapters were written by respected experts in their fields, offering an invaluable reference source for scientists and clinicians interested in FcRs and how to better master antibodies for therapeutic purposes.
Editors and Affiliations
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Institut Pasteur, Paris, France
Marc Daeron
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Department of Biology, Institute of Genetics, University of Erlangen-Nürnberg, Erlangen, Germany
Falk Nimmerjahn
Bibliographic Information
Book Title: Fc Receptors
Editors: Marc Daeron, Falk Nimmerjahn
Series Title: Current Topics in Microbiology and Immunology
DOI: https://doi.org/10.1007/978-3-319-07911-0
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2014
Hardcover ISBN: 978-3-319-07910-3Published: 25 August 2014
Softcover ISBN: 978-3-319-37909-8Published: 23 August 2016
eBook ISBN: 978-3-319-07911-0Published: 12 August 2014
Series ISSN: 0070-217X
Series E-ISSN: 2196-9965
Edition Number: 1
Number of Pages: XV, 424
Number of Illustrations: 11 b/w illustrations, 44 illustrations in colour
Topics: Immunology, Receptors, Molecular Medicine