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Biomedical Sciences - Immunology | Sphingosine-1-Phosphate Signaling in Immunology and Infectious Diseases

Sphingosine-1-Phosphate Signaling in Immunology and Infectious Diseases

Oldstone, Michael B. A., Rosen, Hugh (Eds.)

2014, VII, 184 p. 27 illus., 22 illus. in color.

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  • Written by leading experts in the field
  • Provides a comprehensive and up to date overview on sphingosine-1-phosphate signaling
  • An invaluable source of information for both basic and clinical researchers

This volume focuses on the role of sphingosine-1-phosphate (S1P) and its analogs in the induced sequestration of lymphocytes in secondary lymphoid organs or in the microenvironment of tissues involved in infection or autoimmune disease. Initial chapters define the pathways to understand S1P signaling. They cover the organization of  signaling systems, the structural biology of the S1P1 receptor, and the chemical and genetic tools that are available and useful to explore this area of research and therapeutics. The later chapters highlight S1P and endothelial integrity, lymphocyte migration in the spleen, and S1P agonist in controlling immunopathologic manifestations of acute respiratory influenza virus infection (in the lung), and its accompanying cytokine storm as well as immunopathologic disease of the central nervous system, including the beginning of treatments in multiple sclerosis.  One chapter reveals the possible involvement of other lipid molecules, their use for better understanding lipid signaling, and their potential in the modulation of immune responses.

Content Level » Research

Keywords » CNS inflammation - Cytokine storm - Endothelial integrity - Influenza virus infection - Multiple sclerosis - S1P signaling system

Related subjects » Immunology - Internal Medicine - Virology

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