Overview
- Provides a comprehensive overview on these endogenous antibiotics
- Includes information on role in inflammatory diseases and gives an outlook on new therapeutic options
- Written by experts in the field of antimicrobial/host defense peptide research
- Includes supplementary material: sn.pub/extras
Part of the book series: Progress in Inflammation Research (PIR)
Access this book
Tax calculation will be finalised at checkout
Other ways to access
Table of contents (14 chapters)
-
Front Matter
-
Back Matter
Keywords
About this book
Antimicrobial peptides have been the subject of intense research in the past decades, and are now considered as an essential part of the defense system in bacteria, plants, animals and humans. his book provides an update on these effector molecules of the innate immune system both for researchers who are already actively involved in the area, and for those with a general interest in the topic.
The book starts with an overview of the evolution of cysteine-containing antimicrobial peptides (including defensins), and the role of these peptides in host defense in plants and micro-organisms. The realization that antimicrobial peptides also display functions distinct from their direct antimicrobial action is the focus of the next chapters, and puts these peptides center stage in immunity and wound repair. Further chapters discuss the role of antimicrobial peptides in disease, by providing an overview of mechanisms in bacterial resistance to antimicrobial peptides and a discussion of their role in inflammatory bowel disease, cystic fibrosis lung disease and chronic obstructive pulmonary disease. Finally, the book shows how knowledge of the function of antimicrobial peptides and their regulation can be used to design new therapies for inflammatory and infectious disorders. This is a very important area of research because of the increase in resistance of micro-organisms to conventional antibiotics. Therefore the use of synthetic or recombinant peptides, or agents that stimulate the endogenous production of antimicrobial peptides, provides an attractive alternative for conventional antibiotics.
Editors and Affiliations
Bibliographic Information
Book Title: Antimicrobial Peptides and Innate Immunity
Editors: Pieter S. Hiemstra, Sebastian A. J. Zaat
Series Title: Progress in Inflammation Research
DOI: https://doi.org/10.1007/978-3-0348-0541-4
Publisher: Springer Basel
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer Basel 2013
Hardcover ISBN: 978-3-0348-0540-7Published: 07 February 2013
Softcover ISBN: 978-3-0348-0767-8Published: 07 March 2015
eBook ISBN: 978-3-0348-0541-4Published: 01 February 2013
Series ISSN: 1422-7746
Series E-ISSN: 2296-4525
Edition Number: 1
Number of Pages: XI, 384
Number of Illustrations: 23 b/w illustrations, 20 illustrations in colour
Topics: Immunology, Infectious Diseases, Biochemistry, general, Medical Microbiology