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Biomedical Sciences - Immunology | Therapeutic Antibodies - Methods and Protocols

Therapeutic Antibodies

Methods and Protocols

Series: Methods in Molecular Biology, Vol. 525

Dimitrov, Antony S. (Ed.)

2009, XVIII, 585 p.

A product of Humana Press
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  • Outlines the current state and future trends for therapeutic antibodies
  • Provides complete guidelines to discover and develop therapeutic antibodies, from antigen production to animal studies
  • Presents a modular approach with each part of the book tracing a stage of antibody discovery and preclinical development
  • Details the most recent protocols in antibody discovery and engineering, currently used by leading academic laboratories and biotechnology companies
  • Describes alternate approaches for antibody discovery and characterization

With revenues from the top five therapeutic antibodies accounting for a majority of the recent pharmaceutical sales, the research and development in the field has exploded over the past several years and is expected to grow with new emerging monoclonal antibodies like Numax, Lucentis, Actemra, and others. In Therapeutic Antibodies: Methods and Protocols, leading experts from academic laboratories and biotechnology companies present an extensive set of protocols for the discovery and development of therapeutic antibodies, featuring sections devoted to recombinant antigens, antibody libraries, antibody discovery, antibody engineering, and antibody preclinical development. Written in the highly successful Methods in Molecular Biology™ series format, the chapters contain brief introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes highlighting tips on troubleshooting and avoiding known pitfalls.

Comprehensive and cutting-edge, Therapeutic Antibodies: Methods and Protocols serves as a key resource for researchers and antibody engineers investigating and participating in this rapidly growing therapeutic market segment.

Content Level » Professional/practitioner

Keywords » Antibody discovery - Antibody engineering - Antibody libraries - Antibody preclinical development - Antigen - HIV - Monoclonal antibodies - Recombinant antigens - dynamics

Related subjects » Immunology

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