Biological Amplification Systems in Immunology

1. Front Matter

   Pages i-xv

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2. Biochemistry and Biology of Complement Activation

   • W. Opferkuch, M. Segerling

   Pages 1-16

3. Alternative Modes and Pathways of Complement Activation

   • Henry Gewurz, Thomas F. Lint

   Pages 17-45

4. Complement Synthesis

   • Harvey R. Colten

   Pages 47-67

5. Plasma Membrane Receptors for Complement

   • Celso Bianco

   Pages 69-84

6. Opsonization

   • Frank M. Griffin Jr.

   Pages 85-113

7. Killing of Nucleated Cells by Antibody and Complement

   • Sarkis H. Ohanian, Tibor Borsos

   Pages 115-135

8. Serum Bactericidal Activity and Complement

   • Louis H. Muschel, Jack S. C. Fong

   Pages 137-158

9. Biologic Aspects of Leukocyte Chemotaxis

   • Ralph Snyderman, Marilyn Pike

   Pages 159-181

10. Phylogenetics and Ontogenetics of the Complement Systems

    • Mark Ballow

    Pages 183-204

11. The Chemistry and Biology of the Proteins of the Hageman Factor-Activated Pathways

    • Richard J. Ulevitch, Charles G. Cochrane

    Pages 205-217

12. Isolated Deficiencies of the Complement System in Experimental Animals

    • Hartmut Geiger, Noorbibi K. Day

    Pages 219-228

13. Inherited Deficiencies of the Complement System

    • Noorbibi K. Day, B. Moncada, Robert A. Good

    Pages 229-245

14. Complement and the Major Histocompatibility Systems

    • Casper Jersild, Pablo Rubinstein, Noorbibi K. Day

    Pages 247-275

15. Complement in Cancer

    • Robert L. Kassel, William D. Hardy Jr., Noorbibi K. Day

    Pages 277-294

16. Perturbations of Complement in Disease

    • Irma Gigli

    Pages 295-313

17. Back Matter

    Pages 315-325

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Interest in complement developed at the end of the nineteenth century from observations on cellular and humoral defense mechanisms against bacteria. It was recognized at that time that there were factors in body fluids of animals and man that were capable of killing and lysing bacteria in the absence of cellular factors. Due to the efforts of two of the founders of immunology, Bordet and Ehrlich, and their colleagues, by 1912 the multicomponent nature of complement action was well recognized, the sequence of reaction of the components in the lysis of erythrocytes was defined, complement fixation as a major tool for studying antibody-antigen interaction was well established, and studies on the physicochemical properties of the components had been started. Yet, with a few notable exceptions, research on complement was largely abandoned by most "mainstream" immunologists for the following two or three decades. When one looks at the contents of the present volume, it is hard to imagine that as recently as 20 years ago, there were probably fewer than ten major laboratories where complement research was the primary theme. The contents attest to the fact that there are today dozens of laboratories on three continents where research on complement is pursued in depth. It is not easy to point to all the advances that have occurred in complement research during the past few years.

• antibody
• antigen
• bacteria
• immunology

• Sloan-Kettering Institute for Cancer Research, New York, USA

  Noorbibi K. Day, Robert A. Good

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