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Explores the relationship between the immune system and skeletal structure.
Brings together ideas from both fields.
Fosters a greater cooperation between immunology and osteology
This second edition of this book expands further on the first edition, which explored the relationship between the human immune system and the skeletal structure. In the past, scientists involved in immune and bone-cell investigations have rarely interacted in a significant way, as these disciplines have developed independently and, for the most part, remain separate. This book brings together ideas of international scientists from both fields in pursuit of new collaborations. This may facilitate greater understanding of the relationships between these fields.
Osteoimmunology: An Introduction.- NF-κB and inflammatory bone loss: “alternative” family members take their place at the table.- Adaptive immune responses and bone.- Intracellular calcium signaling for osteoclast differentiation.- Lessons from Glucocorticoid Receptor action in Bone: New ways to avoid side effects of steroid therapy.- A Tak1/p38 signaling axis regulates Runx2 activity and osteoblast functions.- Parathyroid hormone: A dynamic regulator of bone, immune, and hematopoietic cells.- Sphingosine-1-phosphate and chemokines in the control of osteoclast precursors migration visualized by intravital multiphoton microscopy.- T cells mediate the effects of PTH in bone.- The relationship between inflammation, destruction and remodeling in chronic joint diseases.- Regulation of RANKL-induced osteoclastogenesis by TGF-b.- Effects of the Interleukin-1 Cytokine Family on Bone.- DAP12 regulates the osteoclast cytoskeleton Osteoclasts determinanats and implications for therapy.