Current Topics in Innate Immunity II

1. Front Matter

   Pages i-xvii

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2. Pentraxins in Humoral Innate Immunity

   • Antonio Inforzato, Barbara Bottazzi, Cecilia Garlanda, Sonia Valentino, Alberto Mantovani

   Pages 1-20

3. Galectins as Pattern Recognition Receptors: Structure, Function, and Evolution

   • Gerardo R. Vasta

   Pages 21-36

4. The Role of Innate Immunity in Trafficking of Hematopoietic Stem Cells—An Emerging Link Between Activation of Complement Cascade and Chemotactic Gradients of Bioactive Sphingolipids

   • Mariusz Z. Ratajczak, ChiHwa Kim, Wan Wu, Dong Myung Shin, Ewa Bryndza, Magda Kucia et al.

   Pages 37-54

5. Interaction of the Microbiome with the Innate Immune Response in Chronic Wounds

   • Elizabeth A. Grice, Julia A. Segre

   Pages 55-68

6. Pathogenic Microbes and Community Service Through Manipulation of Innate Immunity

   • George Hajishengallis, Jennifer L. Krauss, Shuang Liang, Megan L. McIntosh, John D. Lambris

   Pages 69-85

7. A Conserved Host and Pathogen Recognition Site on Immunoglobulins: Structural and Functional Aspects

   • Bruce D. Wines, Halina M. Trist, William Farrugia, Chloe Ngo, John Trowsdale, Thomas Areschoug et al.

   Pages 87-112

8. Advances in Understanding the Structure, Function, and Mechanism of the SCIN and Efb Families of Staphylococcal Immune Evasion Proteins

   • Brandon L. Garcia, Kasra X. Ramyar, Daniel Ricklin, John D. Lambris, Brian V. Geisbrecht

   Pages 113-133

9. Granzyme B: A New Crossroad of Complement and Apoptosis

   • Mario Perl, Stephanie Denk, Miriam Kalbitz, Markus Huber-Lang

   Pages 135-146

10. Role of C3, C5 and Anaphylatoxin Receptors in Acute Lung Injury and in Sepsis

    • Markus Bosmann, Peter A. Ward

    Pages 147-159

11. Complement Involvement in Neovascular Ocular Diseases

    • Ryoji Yanai, Aristomenis Thanos, Kip M. Connor

    Pages 161-183

12. Platelets, Complement, and Contact Activation: Partners in Inflammation and Thrombosis

    • Osama A. Hamad, Jennie Bäck, Per H. Nilsson, Bo Nilsson, Kristina N. Ekdahl

    Pages 185-205

13. Nuclear Factor-κB in Immunity and Inflammation: The Treg and Th17 Connection

    • Qingguo Ruan, Youhai H. Chen

    Pages 207-221

14. Function of Act1 in IL-17 Family Signaling and Autoimmunity

    • Ling Wu, Jarod Zepp, Xiaoxia Li

    Pages 223-235

15. Differential Effect of Inhibiting MD-2 and CD14 on LPS- Versus Whole E. coli Bacteria-Induced Cytokine Responses in Human Blood

    • D. Christiansen, O. L. Brekke, J. Stenvik, J. D. Lambris, T. Espevik, T. E. Mollnes

    Pages 237-251

16. Zebrafish: Model for the Study of Inflammation and the Innate Immune Response to Infectious Diseases

    • Beatriz Novoa, Antonio Figueras

    Pages 253-275

17. Monocyte-derived Inflammatory Dendritic Cells in the Granuloma During Mycobacterial Infection

    • Heidi A. Schreiber, Matyas Sandor

    Pages 277-293

18. NK/DC Crosstalk in Anti-viral Response

    • Emanuela Marcenaro, Simona Carlomagno, Silvia Pesce, Alessandro Moretta, Simona Sivori

    Pages 295-308

19. Innate-Adaptive Crosstalk: How Dendritic Cells Shape Immune Responses in the CNS

    • Benjamin D Clarkson, Erika Héninger, Melissa G Harris, JangEun Lee, Matyas Sandor, Zsuzsanna Fabry

    Pages 309-333

20. Nutritional Immunity: Homology Modeling of Nramp Metal Import

    • Mathieu F. M. Cellier

    Pages 335-351

Mounting evidence in the past decade indicates that innate immunity mediates functions above and beyond first-line defense against infection. It is now appreciated that innate immune mechanisms are critically involved in the development of adaptive immunity and, moreover, the regulation of diverse physiological and homeostatic processes. The latter explains why deregulation of innate immunity may lead to pathological disorders that are not necessarily or directly related to host defense. This Volume compiles the latest advances in this rapidly evolving field as presented by eminent scientists at the 7th International Aegean Conference on Innate Immunity in Rhodes, Greece. It includes topics related to the biology and function of Toll-like and other pattern-recognition receptors, complement and its crosstalk with other physiological systems, inflammatory mechanisms and diseases, natural killer cells, and the cooperative interplay between innate and adaptive immune cells. This book is an excellent source of information for researchers and clinicians with interests in immunology, host-microbe interactions, and infectious and inflammatory diseases.

• infectious diseases

• Department Of Pathology Laboratory Of, Medicine, University Of Pennsylvania, Philadelphia, USA

  John D. Lambris

• Health Sciences Center, University of Louisville, Louisville, USA

  George Hajishengallis

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