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TH17 Cells in Health and Disease

  • Book
  • © 2011

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Editors:
  1. Shuiping Jiang

    1. King's College London, Department of Nephrology and Transplanta, Guy's Hospital, London, United Kingdom

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  • Includes new information on current discoveries, including the recently identified Interleukin 17 (IL-17) cytokine family.
  • Edited by the founder of the International Conference on Regulatory T Cells and TH17 Cells and Clinical Application in Human Diseases
  • Includes information on the integration of TH17 cells with TH1 and TH2 effector T cells, which is beginning to explain the underlying mechanisms of tissue inflammation in a number of infections and auto-immune disease settings
  • Includes supplementary material: sn.pub/extras

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About this book

“About 25 years ago, Mosmann & Coffman introduced the TH1 / TH2 paradigm of T helper cell differentiation which helped explain many aspects of adaptive immunity from eliminating intracellular versus extracellular pathogens to induction of different types of tissue inflammation. However, TH1 / TH2 paradigm could not adequately explain development of certain inflammatory responses which provided impetus for the discovery of a new subset of T cells called TH17 cells. After the discovery of differentiation and transcription factors for TH17 cells, it was clear that TH17 cells represent an independent subset of T cells with specific functions in eliminating certain extracellular pathogens, presumably not adequately handled by TH1 or TH2 cells. The major role of TH17 cells has been described in inducing auto-immune tissue inflammation. The discovery of TH17 cells has expanded the TH1 / TH2 paradigm, and the integration of TH17 cells with TH1 and TH2 effector T cells is beginning to explain the underlying mechanisms of tissue inflammation in a number of infections and auto-immune disease settings.” - From Chapter One by Vijay K. Kuchroo, Harvard University, USA “The recently identified Interleukin 17 (IL-17) cytokine family contributes to immunity to infectious diseases and chronic inflammatory diseases. Further studies on the regulation and function of this important cytokine family may provide better understanding on the roles of the IL-17 family in immune-mediated diseases; such knowledge may lead to the development of immunotherapeutic strategies for treatment of several inflammatory diseases.” - From Chapter Two by Chen Dong, University of Texas and MD Anderson Cancer Center, USA

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Table of contents (28 chapters)

  1. Front Matter

    Pages i-xiv
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  2. The Immunology of IL-17 Family and TH17 Cells

    1. Front Matter

      Pages 1-1
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    2. From TH1/TH2 Paradigm to TH17 Cells: Le Roi Est Mort, Vive Le Roi

      • Amit Awasthi, Vijay K. Kuchroo
      Pages 3-25

    3. TH17 Cytokines: Characteristics, Regulation, and Biological Function

      • Pornpimon Angkasekwinai, Chen Dong
      Pages 27-40

    4. TGF-beta and TH17 Cells

      • Samuel Huber, Enric Esplugues, Richard A. Flavell
      Pages 41-45

    5. IL-6: A Pleiotropic Cytokine and TH17 Cells

      • Akihiro Kimura, Tetsuji Naka, Tadamitsu Kishimoto
      Pages 47-62

    6. Apoptosis and TH17 Cell Differentiation

      • J. Magarian Blander
      Pages 63-105

    7. IL-1 and Innate Immunity in the Differentiation of TH17 Cells

      • Stephen J. Lalor, Caroline E. Sutton, Kingston H. G. Mills
      Pages 107-127

    8. Negative Regulation of TH17 Differentiation

      • Mark S. Sundrud, Sergei Koralov
      Pages 129-155

    9. Signal Transduction and TH17 Cell Differentiation

      • Xiang-Ping Yang, John J. O’Shea, Kamran Ghoreschi, Arian Laurence
      Pages 157-182

    10. Structure and IL-17 Receptor Signaling

      • Michael Tsang, Sarah L. Gaffen
      Pages 183-201

    11. Trafficking Receptors and Migration of TH17 Cell Subsets

      • Chang H. Kim
      Pages 203-216

    12. Plastic T Cells: Recycling Effector Functions?

      • Eleftherios I. Agorogiannis, Stephen P. Cobbold, Herman Waldmann
      Pages 217-228

  3. TH17 Cells in Health and Disease

    1. Front Matter

      Pages 229-229
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    2. Human TH17 Cells

      • Francesco Annunziato, Lorenzo Cosmi, Francesco Liotta, Enrico Maggi, Sergio Romagnani
      Pages 231-242

    3. TH17 Cytokines in Primary Mucosal Immunity

      • Jay K. Kolls, Shabaana A. Khader
      Pages 243-256

    4. TH17 Cells and IL-23 in Gut Inflammation

      • Giovanni Monteleone, Massimiliano Sarra, Francesco Pallone, Thomas T. MacDonald
      Pages 257-267

    5. The Roles of IL-17A and IL-17F in Mucosal Infection and Allergy

      • Harumichi Ishigame, Susumu Nakae, Yoichiro Iwakura
      Pages 269-297

    6. TH17 Cells in Fungal Infections

      • Teresa Zelante, Antonella De Luca, Luigina Romani
      Pages 299-317

    7. TH17 Cells in Organ Transplantation Rejection and Tolerance

      • Julia Tsang, Ling Lu, Shuiping Jiang
      Pages 319-339
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Editors and Affiliations

  • King's College London, Department of Nephrology and Transplanta, Guy's Hospital, London, United Kingdom

    Shuiping Jiang

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