Clinical Applications of Immunomics

1. Front Matter

   Pages i-xvi

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2. Integrative Systems Approaches to Study Innate Immunity

   • Timothy Ravasi

   Pages 1-13

3. Immunomics: At the Forefront of Innate Immunity Research

   • Hongtao Guan, Steven K Dower, Endre Kiss-Toth

   Pages 15-38

4. Epitope-Based Immunome-Derived Vaccines: A Strategy for Improved Design and Safety

   • Anne S. De Groot, Leonard Moise, Julie A. McMurry, William Martin

   Pages 39-69

5. Immunodeficiencies and Immunome: Diseases and Information Services

   • Mauno Vihinen

   Pages 71-85

6. Immunomics of Immune Rejection

   • Ena Wang, Marianna Sabatino, Francesco M Marincola

   Pages 87-105

7. Spectrum, Function, and Value of Targets Expressed in Neoplastic Mast Cells

   • Peter Valent

   Pages 107-125

8. Structure, Allergenicity, and Cross-Reactivity of Plant Allergens

   • Christian Radauer, Heimo Breiteneder

   Pages 127-151

9. The Live Basophil Allergen Array (LBAA): A Pilot Study

   • Franco H. Falcone, Jing Lin, Neil Renault, Helmut Haas, Gabi Schramm, Bernhard F. Gibbs et al.

   Pages 153-169

10. Emerging Therapies for the Treatment of Autoimmune Myasthenia Gravis

    • Kalliopi Kostelidou, Anastasia Sideri, Konstantinos Lazaridis, Efrosini Fostieri, Socrates J. Tzartos

    Pages 171-204

11. New Diagnostic and Therapeutic Options for the Treatment of Multiple Sclerosis

    • Paolo Riccio, Heinrich Haas, Grazia Maria Liuzzi, Rocco Rossano

    Pages 205-226

12. Glycoimmunomics of Human Cancer: Relevance to Monitoring Biomarkers of Early Detection and Therapeutic Response

    • Mepur H. Ravindranath

    Pages 227-252

13. Translational Immunomics of Cancer Immunoprevention

    • Pier-Luigi Lollini

    Pages 253-268

14. Translational Immunomics of Cancer Immunoprevention

    • Andras Falus

    Pages E1-E1

15. Back Matter

    Pages 269-274

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Innate immunity is one the most evolutionally conserved systems, designed to protect the organism from viruses and bacterial infections, stress and many other types of attacks from the outside world. During the past decade, the capacity of molecular biology and information technology to produce and analyse data have grown exponentially, rapidly reforming many aspects of immunology research in the post-genomics era. As a result, scientific understanding of signalling networks governing the innate immunity response in human tissues and other organisms has evolved beyond recognition, compared to even just a decade ago. Many strategies have been designed over the years to identify novel proteins, which have a crucial role in innate immunity responses by regulating particular signalling pathways. These projects had many advantages, including the definition of novel drug targets, as exemplified by the recent success of anti-TNF therapy, as well as leading to a better, system-wide understanding of the molecular control of innate immunity. In the past few years, a new concept, Immunomics, has been adopted to define an emerging, multidisciplinary field of research (Schonbach, 2003). Although rapid progress has been made to identify the proteins playing pivotal roles in the innate immunity–related signalling pathways (for example, TIR signalling pathways), the catalogue of proteins with a key regulatory function identified and studied is far from completed. Novel proteins need to be char- terised to gain a more comprehensive picture of how signalling networks are regulated.

• bioinformatics
• biology
• databases
• genome
• translation

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