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Mechanisms of Lymphocyte Activation and Immune Regulation XI

B Cell Biology

  • Conference proceedings
  • © 2007

Overview

Editors:
  1. Sudhir Gupta

    1. School of Medicine, College of Health Sciences, University of California, Irvine, USA

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  2. Frederick Alt

    1. Department of Genetics, Children's Hospital Boston, Boston, USA

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  3. Max Cooper

    1. Inst. Medical/Tumor Research Laboratories, University of Alabama, Birmingham, USA

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  4. Fritz Melchers

    1. BiozentrumAbt. Zellbiologie, Max Planck Institute for Infection Biology, Berlin, 4056, Germany

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  5. Klaus Rajewsky

    1. Center for Blood Research, Harvard Medical School, Boston, USA

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  • Discusses the latest developments in the area of lymphocyte activation and immune regulation

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 596)

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Table of contents (18 papers)

  1. Front Matter

    Pages I-IX
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  2. Regulation and Function of the E2A Proteins in B Cell Development

    • Cornelis Murre
    Pages 1-7

  3. Multiple Roles for Blimp-1 in B and T Lymphocytes

    • David Savitsky, Luisa Cimmino, Tracy Kuo, Gislâine A. Martins, Kathryn Calame
    Pages 9-30

  4. Memory B Cell Evolution: B Cell Biology

    • Louise J. McHeyzer-Williams, Michael G. McHeyzer-Williams
    Pages 31-45

  5. BCR-linked Factors in Developmental Fate Decisions

    • Randall J. Brezski, John G. Monroe
    Pages 47-55

  6. Gene Regulatory Networks that Orchestrate the Development of B Lymphocyte Precursors

    • Harinder Singh, Jagan M. R. Pongubala, Kay L. Medina
    Pages 57-62

  7. Rules for the Rearrangement Events at the L Chain Gene Loci of the Mouse

    • Fritz Melchers, Tamotsu Yamagami, Antonius Rolink, Jan Andersson
    Pages 63-70

  8. Regulation of AID Function In Vivo

    • Reiko Shinkura, Il-mi Okazaki, Taro Muto, Nasim A. Begum, Tasuku Honjo
    Pages 71-81

  9. Targeting of AID to Immunoglobulin Genes

    • Ursula Storb, Hong Ming Shen, Simonne Longerich, Sarayu Ratnam, Atsushi Tanaka, Grazyna Bozek et al.
    Pages 83-91

  10. Targeting AID to the Ig Genes

    • Ziqiang Li, Zhonghui Luo, Diana Ronai, Fei Li Kuang, Jonathan U. Peled, Maria D. Iglesias-Ussel et al.
    Pages 93-109

  11. DNA Replication to Aid Somatic Hypermutation

    • Zhenming Xu, Hong Zan, Zsuzsanna Pal, Paolo Casali
    Pages 111-127

  12. Regulation of Activation Induced Deaminase via Phosphorylation

    • Uttiya Basu, Jayanta Chaudhuri, Ryan T. Phan, Abhishek Datta, Frederick W. Alt
    Pages 129-137

  13. Modulation of MHC Class II Signal Transduction by CD19

    • David M. Mills, John C. Stolpa, John C. Cambier
    Pages 139-148

  14. Role of NFUPκB Signaling in Normal and Malignant B Cell Development

    • Yoshiteru Sasaki, Marc Schmidt-Supprian, Emmanuel Derudder, Klaus Rajewsky
    Pages 149-154

  15. Fc Receptor–like Proteins (FCRL): Immunomodulators of B Cell Function

    • GGötz R. A. Ehrhardt, Chuen-Miin Leu, Shuangyin Zhang, Güzide Aksu, Tanisha Jackson, Chris Haga et al.
    Pages 155-162

  16. Tolerance Mechanisms in the Late Phase of the Antibody Response

    • Christopher C. Goodnow, James A. Campbell, Lixin Rui, Carola G. Vinuesa
    Pages 163-168

  17. Role of RS/κDE in B Cell Receptor Editing

    • José Luis Vela, David Nemazee
    Pages 169-172

  18. The Regulation of Receptor Editing

    • Mark S. Schlissel*
    Pages 173-179

  19. B Cell Hyporesponsiveness and Autoimmunity: A New Paradigm

    • Christine Grimaldi, Emil Nashi, Jeganathan Venkatesh, Betty Diamond
    Pages 181-190

  20. Back Matter

    Pages 191-196
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Keywords

About this book

In recent years, major developments have been made in understanding various genetic and epigenetic regulatory processes that are critical for the generation of B cell repertoires. These include the role of chromatin regulation and nuclear organization in understating the IgH gene regulation. A role and mechanism of DNA repair proteins in somatic hypermutation has been elucidated. Genetic mutation studies have been instrumental in providing insight into some of the mechanisms involved in targeting CSR to various switch DNA regions located upstream of C region genes, especially a role of AID motifs, transcription, and R-loops. Recent studies support a dominant role of receptor editing in central B cell tolerance and signaling pathways that regulate receptor editing in self-reactive and non-self-reactive immature B cells. These were some of the topics of discussion at the 11th International Conference on B cell Biology. These proceedings highlight recent developments in lymphocyte development, Ig gene rearrangements and somatic hypermutation, chromatin structure modification, B lymphocyte signaling and fate, receptor editing, and autoimmunity.

Editors and Affiliations

  • School of Medicine, College of Health Sciences, University of California, Irvine, USA

    Sudhir Gupta

  • Department of Genetics, Children's Hospital Boston, Boston, USA

    Frederick Alt

  • Inst. Medical/Tumor Research Laboratories, University of Alabama, Birmingham, USA

    Max Cooper

  • BiozentrumAbt. Zellbiologie, Max Planck Institute for Infection Biology, Berlin, 4056, Germany

    Fritz Melchers

  • Center for Blood Research, Harvard Medical School, Boston, USA

    Klaus Rajewsky

Bibliographic Information

  • Book Title: Mechanisms of Lymphocyte Activation and Immune Regulation XI

  • Book Subtitle: B Cell Biology

  • Editors: Sudhir Gupta, Frederick Alt, Max Cooper, Fritz Melchers, Klaus Rajewsky

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/0-387-46530-8

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2007

  • Hardcover ISBN: 978-0-387-46527-2Published: 06 February 2007

  • Softcover ISBN: 978-1-4419-4283-8Published: 19 November 2010

  • eBook ISBN: 978-0-387-46530-2Published: 21 May 2007

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: X, 198

  • Number of Illustrations: 44 b/w illustrations

  • Topics: Immunology, Infectious Diseases, Microbiology, Virology, Pharmacology/Toxicology

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