Protein Misfolding, Aggregation and Conformational Diseases

1. Front Matter

   Pages i-xxv

   PDF

2. Altered Protein Structure and Enhanced Aggregation/Deposition

   1. Front Matter

      Pages 1-1

      PDF

   2. Aβ-Protein and Alzheimer’s Disease

      1. The Pathogenesis of Alzheimer’s Disease: General Overview

         • Liana G. Apostolova, Jeffrey L. Cummings

         Pages 3-29

      2. Free Radicals, Metal Ions, and Aβ Aggregation and Neurotoxicity

         • Kevin J. Barnham, Cyril C. Curtain, Ashley I. Bush

         Pages 31-47

   3. β-Synuclein and Parkinson’s Disease

      1. Progress in Understanding the Mechanisms of Neuronal Dysfunction and Degeneration in Parkinson’s Disease

         • J. William Langston

         Pages 49-59

      2. Cell Biology of <i>α</i>-Synuclein: Implications in Parkinson’s Disease and Other Lewy Body Diseases

         • Seung-Jae Lee, Yoon Suk Kim

         Pages 111-124

   4. β-Synuclein and Parkinson’s Disease

      1. α-Synuclein Aggregation and Parkinson’s Disease

         • Vladimir N. Uversky

         Pages 61-110

   5. Prion Protein and Prion Diseases

      1. Pathogenesis of Prion Diseases

         • Giuseppe Legname, Stephen J. DeArmond, Fred E. Cohen, Stanley B. Prusiner

         Pages 125-146

      2. Mammalian Prion Protein

         • Ilia V. Baskakov

         Pages 147-163

      3. The Yeast Prion Proteins Sup35p and Ure2p

         • Joanna Krzewska, Ronald Melki

         Pages 165-182

      4. Immunoglobulin Light Chain and Systemic Light-Chain Amyloidosis

         • Marina Ramirez-Alvarado, Janelle K. De Stigter, Elizabeth M. Baden, Laura A. Sikkink, Richard W. McLaughlin, Anya L. Taboas

         Pages 183-197

      5. Pancreatic Islet Amyloid and Diabetes

         • Anne Clark, Jenni Moffitt

         Pages 199-216

      6. β2-Microglobulin and Dialysis-Related Amyloidosis

         • Isobel J. Morten, Eric W. Hewitt, Sheena E. Radford

         Pages 217-239

      7. Serum Amyloid A and AA Amyloidosis

         • Zafer Ali-Khan

         Pages 241-256

3. Point Mutations and Enhanced Protein Deposition

   1. Front Matter

      Pages 257-257

      PDF

   2. Transthyretin and the Transthyretin Amyloidoses

      • Joel N. Buxbaum

      Pages 259-283

   3. Human Lysozyme

      • Mireille Dumoulin, Russell J. K. Johnson, Vittorio Bellotti, Christopher M. Dobson

      Pages 285-308

   4. Serpins and the Diversity of Conformational Diseases

      • Robin W. Carrell

      Pages 309-323

4. Altered Protein Structure and Impaired Function

   1. Front Matter

      Pages 325-325

      PDF

   2. Human Copper-Zinc Superoxide Dismutase and Familial Amyotrophic Lateral Sclerosis

      • Ahmad Galaleldeen, P. John Hart

      Pages 327-344

The second volume continues to fill the gap in protein review and protocal literature while summarizing recent achievements in the understanding of the relationships between protein misfoldings, aggregation, and development of protein deposition disorders. The focus of Part B is the molecular basis of differential disorders.

• cell biology
• molecular mechanisms
• pathophysiology
• physiology
• post-translational modification
• protein structure
• translation

• Department of Biochemistry and Molecular Biology, Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis

  Vladimir N. Uversky

• Institute for Biological Instrumentation, Russian Academy of Sciences, Pushchino, Moscow Region, Russia

  Vladimir N. Uversky

• Department of Chemistry and Biochemistry, University of California, Santa Cruz, USA

  Anthony L. Fink

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