Immunology of Milk and the Neonate

1. Front Matter

   Pages i-xiii

   PDF

2. Breastfeeding and Maternal-Neonatal Interactions. Epidemiological Aspects of Breastfeeding

   1. Characteristics of Human Milk Antibodies and their Effect in Relation to the Epidemiology of Breastfeeding and Infections in a Developing Country

      • Lars Å. Hanson, Fehmida Jalil

      Pages 1-15

   2. T Cell Development in the Fetus and Neonate

      • Christopher B. Wilson, David B. Lewis, B. Keith English

      Pages 17-29

   3. Growth Factors and the Development of Neonatal Host Defense

      • Julie E. Bines, W. Allan Walker

      Pages 31-39

3. Development of the Neonatal Immune System

   1. Amniotic Fluid: The First Feeding of Mucosal Immune Factors

      • Mark G. Cleveland, Mary A. Bakos, Susan M. Hilton, Randall M. Goldblum

      Pages 41-49

   2. Ontogeny of the Secretory IgA System in Humans

      • Itaru Moro, Ichiro Saito, Masatake Asano, Tomihisa Takahashi, Takashi Iwase

      Pages 51-57

   3. IgA-Secreting Cells in the Blood of Premature and Term Infants: Normal Development and Effect of Intrauterine Infections

      • André Nahmias, Barbara Stoll, Ellen Hale, Chris Ibegbu, Harry Keyserling, Wendy Innis-Whitehouse et al.

      Pages 59-69

   4. Development of T Cells with Memory Phenotype in Infancy

      • Anthony R. Hayward, Jesse Groothuis

      Pages 71-76

   5. The Effect of Human Milk, Protein-Fortified Human Milk and Formula on Immunologic Factors of Newborn Infants

      • Demetris Kokinopoulos, Spyros Photopoulos, Natassa Varvarigou, Loanis Kafegidakis, Marietta Xanthou

      Pages 77-85

   6. Ontogeny of the Mucosal Immune Response in Children

      • Allan W. Cripps, Maree Gleeson, Robert L. Clancy

      Pages 87-92

4. Function of Cytokines in the Development of the Immune System

   1. Are Cytokines in Human Milk?

      • Armond S. Goldman, Helen E. Rudloff, Frank C. Schmalstieg

      Pages 93-97

   2. The Developing Gastrointestinal Tract and Milk-Borne Epidermal Growth Factor

      • Otakar Koldovský, John Britton, Diane Davis, Thomas Davis, Judy Grimes, Wuyi Kong et al.

      Pages 99-105

   3. Growth Factor Signal Transduction in Human Intestinal Cells

      • Shu-heh W. Chu, W. Allan Walker

      Pages 107-112

   4. Role of IL-6 in Human Antigen-Specific and Polyclonal IgA Responses

      • Jerry R. McGhee, Kohtaro Fujihashi, Cummins Lue, Kenneth W. Beagley, Jiri Mestecky, Hiroshi Kiyono

      Pages 113-121

   5. Immunological Properties and Differentiation Potential of Human Colostral Lymphocytes of B Cell Lineage

      • Jiri Mestecky, Zina Moldoveanu, Shirley J. Prince, William H. Kutteh, Rose Kulhavy, Jerry R. McGhee et al.

      Pages 123-129

5. Innate Immune Factors

   1. The Effects of Colostrum on Neutrophil Function: Decreased Deformability with Increased Cytoskeleton-Associated Actin

      • E. Stephen Buescher

      Pages 131-136

   2. Peroxidases in Human Milk

      • Kenneth M. Pruitt, Firoz Rahemtulla, Britta Månsson-Rahemtulla, David C. Baldone, George T. Laven

      Pages 137-144

   3. Lactoferrin Binding to its Intestinal Receptor

      • Bo Lönnerdal

      Pages 145-150

   4. Free Fatty Acids and Monoglycerides: Anti-Infective Agents Produced during the Digestion of Milk Fat by the Newborn

      • Margit Hamosh

      Pages 151-158

   5. The Role of Milk-Derived Antimicrobial Lipids as Antiviral and Antibacterial Agents

      • Charles E. Isaacs, Halldor Thormar

      Pages 159-165

In the course of history, humans have attempted to interrupt the physiological and psychological bond formed between a nursing mother and her child by substituting breastfeeding with artificial formulas. A growing body of evidence indicates that breast milk, quite apart from its unsurpassed nutritive value, contains a large number of substances that protect the offspring from common infectious agents and allergens and promote the maturation of the gastrointestinal tract and the immune system. In addition to well described milk antibodies and soluble mediators of innate immunity, milk cells and pluripotent secreted factors - cytokines - are currently in the forefront of extensive research with respect to their importance in milk immunology. The purpose of this conference was to critically evaluate the current state of our knowledge concerning the protective role of immune agents found in milk, to provide up-to-date information of milk factors with respect to their role in the maturation of immunological defense systems in the neonate, and to reassess the importance of breastfeeding in the prevention of allergies in formula-fed infants. We hope that the work presented by international participants will prompt many new ideas and stimulate further research in this important area. This conference was sponsored primarily by the National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD. We would like to thank Drs. Sumner Yaffe and Delbert Dayton for their efforts with the organization, planning, and support of this conference.

• Allergie
• antibody
• child
• cytokine
• cytokines
• development
• immune system
• immunology
• innate immunity
• nursing
• system

• University of Alabama at Birmingham, Birmingham, USA

  Jiri Mestecky

• National Institutes of Health, Bethesda, USA

  Claudia Blair

• University of Texas, Galveston, USA

  Pearay L. Ogra

Policies and ethics