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Cellular Trafficking of Cell Stress Proteins in Health and Disease

  • Book
  • © 2012

Overview

Editors:
  1. Brian Henderson

    1. Eastman Dental Institute, Div. Microbial Diseases, University College, London, London, United Kingdom

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  2. A. Graham Pockley

    1. School of Medicine & Biomedical Science, University of Sheffield, Sheffield, United Kingdom

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    You can also search for this editor in PubMed   Google Scholar

  • The book is written by leaders in the field of heat shock protein research
  • This volume brings together experts in the biochemistry, cellular biology, immunology and molecular biology of molecular chaperones and Protein-Folding Catalysts (PFCs) with a focus on the mechanisms of cellular trafficking of these proteins and the role of these variegated trafficking mechanisms in both human and animal health and disease.
  • The book contains focussed sections covering i) historical aspects of molecular chaperone biology, ii) Intracellular Trafficking of Molecular Chaperones and its Consequences, iii) Molecular Chaperones in Intracellular Trafficking and Function of Immune Receptors, iv) Molecular Chaperones as Cell Surface Receptors, and v) Extracellular Secretion of Molecular Chaperones
  • Includes supplementary material: sn.pub/extras
  • Includes supplementary material: sn.pub/extras

Part of the book series: Heat Shock Proteins (HESP, volume 6)

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Table of contents (18 chapters)

  1. Front Matter

    Pages 1-1
    Download chapter PDF

  2. Discovery of the Cellular Secretion of Cell Stress Proteins

    • Lawrence E. Hightower, Emily J. Noonan
    Pages 1-11

  3. Discovery of the Extracellular Agonist Actions of Molecular Chaperones and Protein-Folding Catalysts

    • Brian Henderson
    Pages 13-27

  4. Molecular Chaperones and Protein-Folding Catalysts in Biological Fluids

    • A. Graham Pockley
    Pages 29-42

  5. Hsp27 Phosphorylation Patterns and Cellular Consequences

    • Ugo Moens, Sergiy Kostenko
    Pages 43-74

  6. Evidence on Cholesterol-Controlled Lipid Raft Interaction of the Small Heat Shock Protein HSPB11

    • Zsolt Török, Ana-Maria Pilbat, Imre Gombos, Enikö Hocsák, Balázs Sümegi, Ibolya Horváth et al.
    Pages 75-85

  7. Hsp70 Chaperone Systems in Vesicular Trafficking

    • J. Paul Chapple, David A. Parfitt, Daniel C. Campbell
    Pages 87-101

  8. Pathways of Hsp70 Release: Lessons from Cytokine Secretion

    • Stuart K Calderwood, Ayesha Murshid
    Pages 103-113

  9. Nucleolin: A Novel Intracellular Transporter of HSPA1A

    • Alexzander Asea, Appukuttan R. Pradeep, Punit Kaur
    Pages 115-124

  10. The Hsp90-Based Protein Trafficking System and Linkage to Protein Quality Control

    • Yoichi Osawa, William B. Pratt, Yoshihiro Morishima, Andrew P. Lieberman
    Pages 125-150

  11. Cell Surface Molecular Chaperones and the LPS Receptor

    • Martha Triantafilou, Kathy Triantafilou
    Pages 151-165

  12. Chaperonin 60: An Unexpected Cell Surface Receptor in Prokaryotes and Eukaryotes

    • Brian Henderson
    Pages 167-183

  13. Pathophysiological Barriers Impeding the Delivery of Heat Shock Protein (HSP)-Based Macromolecules and Nanotherapeutics to Solid Tumors

    • Peter Vaupel, Gabriele Multhoff
    Pages 185-199

  14. The Chaperokine Activity of HSPA1A

    • Alexzander Asea, Punit Kaur
    Pages 201-213

  15. Molecular Chaperones and Scavenger Receptors: Binding and Trafficking of Molecular Chaperones by Class F and Class H Scavenger Receptors

    • Ayesha Murshid, Jianlin Gong, Stuart K. Calderwood
    Pages 215-227

  16. GRP78 (BiP): A Multifunctional Cell Surface Receptor

    • Mario Gonzalez-Gronow, Salvatore V. Pizzo, Uma K. Misra
    Pages 229-242

  17. Mycobacterium tuberculosis Hsp60 as a Key Virulence Factor in Tuberculosis

    • Richard W. Stokes
    Pages 243-258

  18. Heat Shock Protein 90 Versus Conventional Growth Factors in Acute and Diabetic Wound Healing

    • Wei Li, Kathryn O’Brien, David T. Woodley, Mei Chen
    Pages 259-277

  19. Circulating Chaperones in Health and Disease

    • Zoltán Prohászka
    Pages 279-290

  20. Back Matter

    Pages 281-281
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Keywords

About this book

Since the beginning of the 21st Century there has been a rapid increase in our understanding of the cellular trafficking mechanisms of molecular chaperones in eukaryotes and in prokaryotes. In the former, molecular chaperone trafficking can occur between the various cellular compartments, with concomitant movement of other proteins. Such events can also result in the release of molecular chaperones from cells. In bacteria, molecular chaperones are involved in the trafficking of other proteins and are themselves released into the external milieu. The increasing appreciation of the role of molecular chaperones and Protein-Folding Catalysts in the interplay between bacteria and the cells of their hosts is now an important area of research for understanding the mechanisms of infectious diseases. This volume brings together experts in the biochemistry, cellular biology, immunology and molecular biology of molecular chaperones and Protein-Folding Catalysts with a focus on the mechanisms of cellular trafficking of these proteins and the role of these variegated trafficking mechanisms in both human and animal health and disease.

Editors and Affiliations

  • Eastman Dental Institute, Div. Microbial Diseases, University College, London, London, United Kingdom

    Brian Henderson

  • School of Medicine & Biomedical Science, University of Sheffield, Sheffield, United Kingdom

    A. Graham Pockley

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