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Pathologies of Calcium Channels

  • Book
  • © 2014

Overview

Editors:
  1. Norbert Weiss

    1. Hotchkiss Brain Institute, Department of Physiology and Pharmacology, University of Calgary, Calgary, Canada

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    You can also search for this editor in PubMed   Google Scholar

  2. Alexandra Koschak

    1. Department of Neurophysiology and Pharmacology, Medical University Vienna, Vienna, Austria

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Provides comprehensive information on the molecular basis and the clinical implications
  • Improves the understanding of this rapidly expanding field
  • With contributions by international experts

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Table of contents (34 chapters)

  1. Front Matter

    Pages i-xviii
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  2. Pathologies of Voltage-Gated Calcium Channels

    1. Front Matter

      Pages 1-1
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    2. Cav2.1 Channels and Migraine

      • Daniela Pietrobon
      Pages 3-25

    3. Ataxia and CACNA1A: Episodic or Progressive?

      • Stephanie Schorge, Kinya Ishikawa
      Pages 27-45

    4. Role of L-Type Ca2+ Channels in Sensory Cells

      • Alexandra Koschak, Alexandra Pinggera, Klaus Schicker, Jörg Striessnig
      Pages 47-75

    5. T-Type Calcium Channels and Epilepsy

      • Stuart M. Cain, Michael E. Hildebrand, Terrance P. Snutch
      Pages 77-96

    6. The Involvement of Calcium Channel α2δ Subunits in Diseases and as a Therapeutic Target

      • Annette C. Dolphin
      Pages 97-114

    7. T-Type Calcium Channels in Pain Neuronal Circuits

      • Amaury Francois, Anne Pizzoccaro, Sophie Laffray, Emmanuel Bourinet
      Pages 115-133

    8. Cav1.1 Channel and Hypokalemic Periodic Paralysis

      • Emma Matthews, Michael G. Hanna
      Pages 135-149

    9. Cav1.1 in Malignant Hyperthermia

      • Viktor Yarotskyy, Robert T. Dirksen
      Pages 151-165

    10. Ryanodine Receptor 1 and Associated Pathologies

      • Julien Fauré, Joël Lunardi, Nicole Monnier, Isabelle Marty
      Pages 167-187

    11. The Lambert-Eaton Myasthenic Syndrome

      • Paul W. Wirtz, Maarten J. Titulaer, Jan J. G. M. Verschuuren
      Pages 189-204

    12. Alternative Exon Effect on Phenotype of Cav1.2 Channelopathy: Implications in Timothy Syndrome

      • Hua Huang, Juejin Wang, Tuck Wah Soong
      Pages 205-224

    13. Brugada Syndrome and Voltage-Gated Calcium Channels

      • Brett Simms
      Pages 225-238

    14. Cav1.3 Channels and Sino-Atrial Node Dysfunction

      • Pietro Mesirca, Matteo E. Mangoni
      Pages 239-254

    15. Auxiliary β-Subunits of L-Type Ca2+ Channels in Heart Failure

      • Jan Matthes, Stefan Herzig
      Pages 255-275

    16. Epigenetic, Genetic, and Acquired Regulation of Cav3 T-Type Calcium Channel Expression and Function in Tumor Growth and Progression

      • Maria Beatrice Morelli, Sonia Liberati, Consuelo Amantini, Matteo Santoni, Massimo Nabissi, Valerio Farfariello et al.
      Pages 277-295

    17. Pharmacology of Voltage-Gated Calcium Channels in Clinic

      • Lubica Lacinová, Lucia Lichvárová
      Pages 297-314

  3. Pathologies of Transient Receptor Potential Channels

    1. Front Matter

      Pages 315-315
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    2. TRPM1 and Congenital Stationary Night Blindness

      • Shoichi Irie, Takahisa Furukawa
      Pages 317-331
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Keywords

About this book

Calcium ions represent Mother Nature’s ‘ion-of-choice’ for regulating fundamental physiological functions, as they initiate a new life at the time of fertilization and guide subsequent developmental and physiological functions of the human body. Calcium channels, which act as gated pathways for the movement of calcium ions across the membranes, play a central part in the initiation of calcium signals, and defects in calcium channel function have been found to result in a plethora of human diseases, referred to as the calcium channelopathies.

Pathologies of Calcium Channels brings together leading international experts to discuss our current understanding of human diseases associated with the various calcium channels, from their molecular basis to potential future therapeutic targeting of calcium channels.

Editors and Affiliations

  • Hotchkiss Brain Institute, Department of Physiology and Pharmacology, University of Calgary, Calgary, Canada

    Norbert Weiss

  • Department of Neurophysiology and Pharmacology, Medical University Vienna, Vienna, Austria

    Alexandra Koschak

Bibliographic Information

  • Book Title: Pathologies of Calcium Channels

  • Editors: Norbert Weiss, Alexandra Koschak

  • DOI: https://doi.org/10.1007/978-3-642-40282-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2014

  • Hardcover ISBN: 978-3-642-40281-4Published: 26 November 2013

  • Softcover ISBN: 978-3-662-52353-7Published: 23 August 2016

  • eBook ISBN: 978-3-642-40282-1Published: 09 November 2013

  • Edition Number: 1

  • Number of Pages: XVIII, 731

  • Number of Illustrations: 29 b/w illustrations, 54 illustrations in colour

  • Topics: Human Physiology, Receptors, Neurochemistry, Internal Medicine

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