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  • Reference work
  • © 2014

Systems Biology of Free Radicals and Antioxidants

Editors:

  • The focus of this collection is to present the systems biology of free radicals and anti-oxidants.

  • Free radical induced cellular damage in a variety of tissues and organs are discussed by experts in the field.

  • The utility of various anti-oxidants (plant derived and synthetic) is evaluated with the view to developing site-specific therapies.

  • Includes supplementary material: sn.pub/extras

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Table of contents (181 entries)

  1. Front Matter

    Pages 1-61
  2. General Topics

    1. Front Matter

      Pages 1-1
    2. Free Radicals and Antioxidants for Non-Experts

      • Zdeňka Ďuračková
      Pages 3-38
    3. Free Radicals – An Evolutionary Perspective

      • Pat Monaghan, David Costantini
      Pages 39-64
    4. Biomarkers of Oxidative Stress

      • Frazer Lowe
      Pages 65-87
    5. Oxidative Stress and Cell Function

      • Simon V. Avery
      Pages 89-112
    6. Reactive Oxygen Species and Apoptosis

      • Neelam Azad, Anand Krishnan V. Iyer
      Pages 113-135
    7. Free Radicals in Aging – An Evolutionary Perspective

      • Anna Csiszar, Zoltan Ungvari
      Pages 137-151
    8. Exploring the Effect of Redox Enzyme Modulation on the Biology of Mouse Aging

      • Adam B. Salmon, Arlan Richardson, Viviana I. Pérez
      Pages 153-170
    9. Pathophysiological Roles of Reactive Oxygen and Nitrogen Species

      • Joanne Kilgour, Ruth Roberts
      Pages 171-206
    10. Peroxynitrite Biology

      • Gnanapragasam Arunachalam, Samson Mathews Samuel, Hong Ding, Chris R. Triggle
      Pages 207-242
    11. Mitochondrial Superoxide Flashes – From Signaling to Disease

      • Xianhua Wang, Qi Ma, Wang Wang, Heping Cheng
      Pages 243-263
    12. Mitochondrial and Free Radical Metabolism – Biological and Pathological Implications

      • Lucie Duluc, Ramaroson Andriantsitohaina, Gilles Simard
      Pages 279-293
    13. Mitochondrial Targeting of Antioxidants

      • R. A. Zinovkin, L. E. Bakeeva, B. V. Chernyak, M. V. Egorov, N. K. Isaev, N. G. Kolosova et al.
      Pages 323-354
    14. Oxidative Stress and Ion Channels

      • Hamid I. Akbarali
      Pages 355-373
    15. Free Radical Biology in Hypothermia

      • Duško P. Blagojević
      Pages 375-391
    16. The Effects of High-Altitude Exposure on Reactive Oxygen and Nitrogen Species

      • Zsolt Radak, Zoltan Acs, Zoltan Bori, Albert W. Taylor, Hu Yang
      Pages 407-416

About this book

The focus of this collection of illustrated reviews is to discuss the systems biology of free radicals and anti-oxidants. Free radical induced cellular damage in a variety of tissues and organs is reviewed, with detailed discussion of molecular and cellular mechanisms. The collection is aimed at those new to the field, as well as clinicians and scientists with long standing interests in free radical biology. A feature of this collection is that the material also brings insights into various diseases where free radicals are thought to play a role. There is extensive discussion of the success and limitations of the use of antioxidants in several clinical settings.

Editors and Affiliations

  • Department of Pharmacology and Therapeutics, University of British Colombia, Vancouver, Canada

    Ismail Laher

About the editor

Ismail (Issy) Laher, Ph.D., is a Professor at the Department of Pharmacology and Therapeutics at the Faculty of Medicine of the University of British Columbia in Vancouver,Canada. He is also a Visiting Professor at the Department of Pharmacology at the University of Vermont, USA.  Trained at the University of London in pharmacology, he then continued with additional training in cardiovascular pharmacology at UBC and UVM, with a focus on the regulation of resistance artery regulation in health and disease.

Bibliographic Information

Buy it now

Buying options

eBook USD 1,999.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book USD 2,999.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access