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Tissue-Specific Estrogen Action

Novel Mechanisms, Novel Ligands, Novel Therapies

  • Conference proceedings
  • © 2007

Overview

Editors:
  1. K. S. Korach
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  2. T. Wintermantel
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Part of the book series: Ernst Schering Foundation Symposium Proceedings (SCHERING FOUND, volume 2006/1)

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Table of contents (10 papers)

  1. Front Matter

    Pages i-xv
    Download chapter PDF

  2. Interfering with the Dynamics of Estrogen Receptor-Regulated Transcription

    • S. A. Johnsen, S. Kangaspeska, G. Reid, F. Gannon
    Pages 1-12

  3. Actions of Estrogen and Estrogen Receptors in Nonclassical Target Tissues

    • E. Murphy, K. S. Korach
    Pages 13-24

  4. Genetic Dissection of Estrogen Receptor Signaling In Vivo

    • T. M. Wintermantel, J. Elzer, A. E. Herbison, K.-H. Fritzemeier, G. Schütz
    Pages 25-44

  5. Of Mice and Men: The Many Guises of Estrogens

    • E. R. Simpson, M. E. Jones
    Pages 45-68

  6. Estradiol Action in Atherosclerosis and Reendothelialization

    • J.- F. Arnal, H. Laurell, F. Lenfant, V. Douin-Echinard, L. Brouchet, P. Gourdy
    Pages 69-86

  7. Functional Effects and Molecular Mechanisms of Subtype-Selective ERα and ERβ Agonists in the Cardiovascular System

    • P. A. Arias-Loza, V. Jazbutyte, K.-H. Fritzemeier, C. Hegele-Hartung, L. Neyses, G. Ertl et al.
    Pages 87-106

  8. Pathogenesis and Therapy of Rheumatoid Arthritis

    • R. O. Williams
    Pages 107-130

  9. The Role of ERα and ERβ in theProstate: Insights from Genetic Models and Isoform-Selective Ligands

    • S. J. McPherson, S. J. Ellem, V. Patchev, K. H. Fritzemeier, G. P. Risbridger
    Pages 131-148

  10. Preclinical Characterization of Selective Estrogen Receptor β Agonists: New Insights into Their Therapeutic Potential

    • H. A. Harris
    Pages 149-162

  11. Exploiting Nongenomic Estrogen Receptor-Mediated Signaling for the Development of Pathway-Selective Estrogen Receptor Ligands

    • C. Otto, S. Wessler, K.-H. Fritzemeier
    Pages 163-181

  12. Back Matter

    Pages 183-183
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Keywords

About this book

Nuclear hormone receptors are not only important drug targets, but have also been the focus of decades of active and highly insightful research. Ten years ago, a review on nuclear receptors was entitled “The Second Decade” and a special issue of Molecular Endocrinology in 2005 dealt with the results of these research efforts. The consensus from nuclear receptor research was of course that the signaling pathways mediated by these receptors warrant further research, even though in principle they appeared to represent the most immediate, seemingly simple signaling pathway from hormone (ligand) binding to gene expression changes. In nuclear receptor molecular biology, estrogen receptor research has additional unique facets: since the discovery of ethinyl estradiol by Inhoffen and Hohlweg in the laboratories of Schering AG in the 1930s—and therefore several decades longer than nuclear receptor - searchitself—estrogenreceptorshavebeentargetsofwidelyused,orally administered drugs. Thus, accumulating clinical experience on estrogen action in vivo helps to support the progress in molecular biological research.

Reviews

From the reviews:

"This summation of a symposium discusses some of the new research developments and estrogen-receptor based therapies that are being tested in the laboratory and in current use. … It is written for researchers, physician scientists, and those interested in estrogen receptor interactions at a molecular level. Hopefully, it can also stimulate interest in and future research by graduate students or clinical/basic researchers." (Amber R. Cooper, Doody’s Review Service, January 2008)

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