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Hyperglycemia, Diabetes and Vascular Disease

  • Book
  • © 1992

Overview

Editors:
  1. Neil Ruderman

    1. Diabetes and Metabolism Unit, Evans Memorial Department of Clinical Research and Department of Physiology, Boston University School of Medicine, Boston, USA

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  2. Joseph Williamson

    1. Department of Pathology, Washington University School of Medicine, St. Louis, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Michael Brownlee

    1. Diabetes Research Center and Departments of Medicine and Pathology, Albert Einstein College of Medicine, Bronx, USA

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    You can also search for this editor in PubMed   Google Scholar

  • There are over 12 million people with diabetes in the US
  • The authors review clinical, epidemiological, and biochemical evidence that high levels of blood glucose produce metabolic and biochemical alterations in vascular walls
  • Based on a 1989 FASEB symposium by the APS

Part of the book series: Clinical Physiology (CLINPHY)

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xi
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  2. Epidemiology and Physiology

    1. Front Matter

      Pages 1-1
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    2. Hyperglycemia, Diabetes, and Vascular Disease: An Overview

      • Neil B. Ruderman, Sandeep Gupta, Ilene Sussman
      Pages 3-20

    3. Epidemiology of Hyperglycemia and Atherosclerosis

      • Peter W. F. Wilson, William B. Kannel
      Pages 21-29

    4. Altered Platelet Function in Diabetes Mellitus: Effect of Glycemic Regulation and Antiplatelet Agents

      • John A. Colwell, Christoph Gisinger, Richard Klein
      Pages 30-47

    5. Diabetes Mellitus and the Vascular Endothelium

      • Richard A. Cohen, Belay Tesfamariam
      Pages 48-58

    6. Cerebral Microvascular Transport and Metabolism: Implications for Diabetes

      • Anthony L. McCall
      Pages 59-103

  3. Polyols, myo-Inositol, and Signal Transduction

    1. Front Matter

      Pages 105-105
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    2. Mechanisms of Glucose- and Diabetes-Induced Vascular Dysfunction

      • Joseph R. Williamson, Charles Kilo, Ronald G. Tilton
      Pages 107-132

    3. Mechanisms of Early Hyperglycemia-Induced Alterations in Vascular Metabolism and Autoregulation

      • Albert I. Winegrad, David A. Simmons
      Pages 133-150

    4. Dissociation of Retinopathy and Nephropathy in Animal Models of Diabetes: Diabetes vs Galactosemia

      • Ronald L. Engerman, Timothy S. Kern
      Pages 151-161

    5. Cell Culture Model for the Study of Vascular Complications of Diabetes: The Effect of High Glucose Levels on Metabolism and Growth of Vascular Cells

      • George L. King, Teruo Shiba, Edward P. Feener, Ramesh Nayak
      Pages 162-177

    6. Mobilization of Arachidonic Acid from Diacyl and Ether Phospholipids in Cultured Endothelial Cells

      • Michael L. Brown
      Pages 178-194

  4. Glycation Products and Glycosoaminoglycans

    1. Front Matter

      Pages 195-195
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    2. Glycation and Autoxidation of Proteins in Aging and Diabetes

      • Timothy J. Lyons, Suzanne R. Thorpe, John W. Baynes
      Pages 197-217

    3. Nonenzymatic Glycosylation of Macromolecules: Prospects for Pharmacologic Modulation

      • Hans-Peter Hammes, Michael Brownlee
      Pages 218-227

    4. Cell-Mediated Interactions of Advanced Glycosylation End Products and the Vascular Wall

      • Helen Vlassara
      Pages 228-242

    5. Effects of Nonenzymatic Glycation on Molecular Interactions of Basement Membrane Molecules

      • Aristidis S. Charonis, Effie C. Tsilibary, Leo T. Furcht
      Pages 243-262

    6. Effects of Diabetes on Kidney Proteoglycans

      • David J. Klein
      Pages 263-281

  5. Back Matter

    Pages 283-300
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Keywords

About this book

It is estimated that 1-5% ofthe world's population is affected by some form of diabetes. Patients with these disorders are highly likely to develop microvas­ cular pathology in the retina and glomerulus and they are at a 2--6-fold greater risk for atherosclerotic vascular disease than individuals without diabetes. In addition, hypertension is far more prevalent in patients with diabetes than in the general population. As a consequence of these complications, diabetes is a leading cause of blindness and renal failure in young and middle-aged adults and it is a major risk factor for coronary heart disease, stroke and peripheral vascular disease in the Western world. An understanding of the relationship of these vascular complications to diabetic hyperglycemia has become a critical issue for clinicians in recent years, since the prevalence of diabetes appears to be increasing dramatically world-wide. In addition, it is now possible to achieve improved glycemic control in many patients-although not without incurring other risks. This volume explores two principal hypotheses concerning these complications. One is that hyperglycemia underlies or at least contributes to the pathogenesis of both micro- and macrovascular disease in patients with diabetes. The other is that it does so by producing specific metabolic and biochemical alterations in the vascular wall that lead to abnormalities in its function and ultimately its structure.

Editors and Affiliations

  • Diabetes and Metabolism Unit, Evans Memorial Department of Clinical Research and Department of Physiology, Boston University School of Medicine, Boston, USA

    Neil Ruderman

  • Department of Pathology, Washington University School of Medicine, St. Louis, USA

    Joseph Williamson

  • Diabetes Research Center and Departments of Medicine and Pathology, Albert Einstein College of Medicine, Bronx, USA

    Michael Brownlee

Bibliographic Information

  • Book Title: Hyperglycemia, Diabetes and Vascular Disease

  • Editors: Neil Ruderman, Joseph Williamson, Michael Brownlee

  • Series Title: Clinical Physiology

  • DOI: https://doi.org/10.1007/978-1-4614-7524-8

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: American Physiological Society 1992

  • eBook ISBN: 978-1-4614-7524-8Published: 27 May 2013

  • Edition Number: 1

  • Number of Pages: 320

  • Additional Information: Originally Published by Oxford University Press 1992

  • Topics: Human Physiology

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