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Endothelin

  • Book
  • © 1992

Overview

Editors:
  1. Gabor M. Rubanyi

    1. Institute of Pharmacology, Research Center, Schering AG, Berlin, Germany

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  • Focuses on Endothelin and its molecular biology, biosynthesis, biological actions, and potential physiological and pathological importance
  • Summarizes history of this unique peptide
  • Comprehensive monograph is an indispensable reference for basic scientists and clinicians

Part of the book series: Clinical Physiology (CLINPHY)

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-1
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  2. Endothelium-Derived Contracting Factors

    • Paul M. Vanhoutte, Thomas Gräser, Thomas F. Lüscher
    Pages 3-16

  3. From Endotensin to Endothelin: The Discovery and Characterization of an Endothelial Cell—Derived Constricting Factor

    • Robert F. Highsmith
    Pages 17-30

  4. Molecular Biology of Endothelins

    • Penny E. Phillips, Christina Cade, Lynne H. Parker Botelho, Gabor M. Rubanyi
    Pages 31-40

  5. Endothelin Structure and Structure—Activity Relationships

    • Paul W. Erhardt
    Pages 41-57

  6. Endothelin Receptors and Receptor Subtypes

    • Hitoshi Miyazaki, Motohiro Kondoh, Yasushi Masuda, Hirotoshi Watanabe, Kazuo Murakami
    Pages 58-71

  7. Tissue Specificity of Endothelin Synthesis and Binding

    • Lynne H. Parker Botelho, Christina Cade, Penny E. Phillips, Gabor M. Rubanyi
    Pages 72-102

  8. Cellular Actions of Endothelin in Vascular Smooth Muscle

    • Tommy A. Brock, N. Raju Danthuluri
    Pages 103-124

  9. Interaction between Endothelin and Endothelium-Derived Relaxing Factor(s)

    • Thomas F. Lüscher, Chantal Boulanger, Zhihong Yang, Yasuaki Dohi
    Pages 125-136

  10. Endothelin as a Growth Factor in Vascular Remodeling and Vascular Disease

    • Victor J. Dzau, Richard E. Pratt, John P. Cooke
    Pages 137-143

  11. Endothelin and the Heart

    • Winifred G. Nayler, Xin Hua Gu
    Pages 144-157

  12. Renal and Systemic Hemodynamic Actions of Endothelin

    • Andrew J. King, Barry M. Brenner
    Pages 158-178

  13. Endothelin, a Ubiquitous Peptide: Morphological Demonstration of Immunoreactive and Synthetic Sites and Receptors in the Respiratory Tract and Central Nervous System

    • S. J. Gibson, D. R. Springall, Julia M. Polak
    Pages 179-208

  14. Endothelin in Human Disease. I: Essential Hypertension, Vasospastic Angina, Acute Myocardial Infarction, and Chronic Renal Failure

    • Yoshihiko Saito, Kazuwa Nakao, Hiroo Imura
    Pages 209-220

  15. Endothelin in Human Disease. II: Shock, Pulmonary Hypertension, and Congestive Heart Failure

    • Duncan J. Stewart
    Pages 221-237

  16. Endothelin and the Homeostatic Function of the Endothelial Cell

    • Regina M. Botting, John R. Vane
    Pages 238-257

  17. Hypothetical Role of Endothelin in the Control of the Cardiovascular System

    • Gabor M. Rubanyi, John T. Shepherd
    Pages 258-271

  18. Back Matter

    Pages 273-277
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Keywords

About this book

Merely three years after the discovery of endothelin, a large amount of information has been generated about the molecular biology, biosynthesis, biological actions and potential physiological and pathological importance of this unique peptide and its isoforms. This first book on endothelins summarizes the early events which lead to the discovery of endothelin, the progress made in understanding the peptide's physiological role, and the current state-of-the-art in contemporary endothelin research. The book also discusses the potential significance of endothelins in health and disease, covers the potential role of the peptides in the integrated control of the cardiovascular system, and outlines future research directions. This comprehensive monograph is an indispensable reference for basic scientists and clinicians.

Editors and Affiliations

  • Institute of Pharmacology, Research Center, Schering AG, Berlin, Germany

    Gabor M. Rubanyi

Bibliographic Information

  • Book Title: Endothelin

  • Editors: Gabor M. Rubanyi

  • Series Title: Clinical Physiology

  • DOI: https://doi.org/10.1007/978-1-4614-7514-9

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: American Physiological Society 1992

  • eBook ISBN: 978-1-4614-7514-9Published: 27 May 2013

  • Edition Number: 1

  • Number of Pages: 306

  • Additional Information: Originally Published by Oxford University Press 1992

  • Topics: Human Physiology

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