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Ribosomes Structure, Function, and Dynamics

  • Book
  • © 2011

Overview

Editors:
  1. Marina V. Rodnina

    1. Department of Physical Biochemistry, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany

  2. Wolfgang Wintermeyer

    1. Department of Physical Biochemistry, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany

  3. Rachel Green

    1. Howard Hughes Medical Institute Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, USA

  • First ribosome book since 2001
  • Nobel Prize Chemistry 2009 - The Ribosome
  • Includes chapters of all three Nobel Prize winners
  • Comprehensive in scope
  • Includes supplementary material: sn.pub/extras

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About this book

The ribosome is a macromolecular machine that synthesizes proteins with a high degree of speed and accuracy. Our present understanding of its structure, function and dynamics is the result of six decades of research. This book collects over 40 articles based on the talks presented at the 2010 Ribosome Meeting, held in Orvieto, Italy, covering all facets of the structure and function of the ribosome. New high-resolution crystal structures of functional ribosome complexes and cryo-EM structures of translating ribosomes are presented, while partial reactions of translation are examined in structural and mechanistic detail, featuring translocation as a most dynamic process. Mechanisms of initiation, both in bacterial and eukaryotic systems, translation termination, and novel details of the functions of the respective factors are described. Structure and interactions of the nascent peptide within, and emerging from, the ribosomal peptide exit tunnel are addressed in several articles. Structural and single-molecule studies reveal a picture of the ribosome exhibiting the energy landscape of a processive Brownian machine. The collection provides up-to-date reviews which will serve as a source of essential information for years to come.

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Table of contents (33 chapters)

  1. Front Matter

    Pages I-IX
    Download chapter PDF

  2. Ribosome structure

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Ribosome crystallography: From early evolution to contemporary medical insights

      • Anat Bashan, Ada Yonath
      Pages 3-18

    3. Structural studies on decoding, termination and translocation in the bacterial ribosome

      • Venki Ramakrishnan
      Pages 19-30

    4. Structural studies of complexes of the 70S ribosome

      • C. Axel Innis, Gregor Blaha, David Bulkley, Thomas A. Steitz
      Pages 31-43

    5. Interaction of bacterial ribosomes with mRNA and tRNA as studied by X-ray crystallographic analysis

      • Lasse B. Jenner, Natalia Demeshkina, Gulnara Yusupova, Marat Yusupov
      Pages 45-55

    6. Genetic and crystallographic approaches to investigating ribosome structure and function

      • Steven T. Gregory, Hasan Demirci, Jennifer F. Carr, Riccardo Belardinelli, Jill R. Thompson, Dale Cameron et al.
      Pages 57-64

    7. The packing of ribosomes in crystals and polysomes

      • Jack A. Dunkle, Jamie H. D. Cate
      Pages 65-73

    8. Crystal structure of the eukaryotic 80S ribosome

      • Adam Ben-Shem, Lasse B. Jenner, Gulnara Yusupova, Marat Yusupov
      Pages 75-81

    9. Structure and function of organellar ribosomes as revealed by cryo-EM

      • Rajendra K. Agrawal, Manjuli R. Sharma, Aymen Yassin, Indrajit Lahiri, inda L. Spremulli
      Pages 83-96

    10. Modifications of ribosomal RNA: From enzymes to function

      • Petr V. Sergiev, Anna Y. Golovina, Irina V. Prokhorova, Olga V. Sergeeva, Ilya A. Osterman, Mikhail V. Nesterchuk et al.
      Pages 97-110

  3. Recruiting the ribosome for translation

    1. Front Matter

      Pages 111-111
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    2. Insights into translation initiation and termination complexes and into the polysome architecture

      • Angelita Simonetti, Stefano Marzi, Alexander G. Myasnikov, Jean-François Ménétret, Bruno P. Klaholz
      Pages 113-128

    3. Initiation of bacterial protein synthesis with wild type and mutated variants of initiation factor 2

      • Michael Y. Pavlov, Suparna Sanyal, Måns Ehrenberg
      Pages 129-141

    4. Translation initiation at the root of the cold-shock translational bias

      • Claudio O. Gualerzi, Anna Maria Giuliodori, Anna Brandi, Fabio Di Pietro, Lolita Piersimoni, Attilio Fabbretti et al.
      Pages 143-154

    5. Recruiting knotty partners: The roles of translation initiation factors in mRNA recruitment to the eukaryotic ribosome

      • Sarah F. Mitchell, Sarah E. Walker, Vaishnavi Rajagopal, Colin Echeverría Aitken, Jon R. Lorsch
      Pages 155-169

    6. The mechanism of ribosome recycling in eukaryotes

      • Andrey V. Pisarev, Maxim A. Skabkin, Vera P. Pisareva, Olga V. Skabkina, Christopher U. T. Hellen, Tatyana V. Pestova
      Pages 171-185

  4. Decoding, fidelity, and peptidyl transfer

    1. Front Matter

      Pages 187-187
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    2. The specific interaction between aminoacyl-tRNAs and elongation factor Tu

      • Jared M. Schrader, Margaret E. Saks, Olke C. Uhlenbeck
      Pages 189-198

    3. Mechanisms of decoding and peptide bond formation

      • Marina V. Rodnina
      Pages 199-212
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Editors and Affiliations

  • Department of Physical Biochemistry, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany

    Marina V. Rodnina, Wolfgang Wintermeyer

  • Howard Hughes Medical Institute Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, USA

    Rachel Green

About the editors

Dr. Marina V. Rodnina

Prof. Dr. Wolfgang Wintermeyer

MPI for Biophysical Chemistry, Dept. of Physical Biochemistry,  Goettingen, Germany

Dr. Rachel Green

Dept. of Molecular Biology and Genetics, Investigator, Howard Hughes Medical Institute,

Johns Hopkins University School of Medicine, Baltimore, MD, USA

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