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Biomedical Sciences - Human Genetics | Epigenetic Mechanisms in Cellular Reprogramming

Epigenetic Mechanisms in Cellular Reprogramming

Meissner, Alexander, Walter, Jörn (Eds.)

2015, XVIII, 230 p. 20 illus., 19 illus. in color.

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  • Contains translational medicine aspects such as B cell programming and reprogramming in cancer
  • Includes extensive glossary
  • Understanding stem cell formation is key to develop novel drugs    

The ability of a single genome to give rise to hundreds of functionally distinct cell type programs is in itself remarkable. Pioneering studies over the past few decades have demonstrated that this plasticity is retained throughout development, a phenomenon of epigenetic programming and reprogramming that remains one of the most fascinating areas of modern biology, with major relevance to human health and disease. This book presents the basic biology involved, including key mechanistic insights into this rapidly growing field.

Content Level » Research

Keywords » DNA methylation - X-chromosome silencing - germline development - reprogramming - small RNAs - sperm epigenome

Related subjects » Cell Biology - Human Genetics

Table of contents 

Stella and zygotic reprogramming by Toshinobu Nakamura and Toru Nakano.- Histone variants and reprogramming in early development by Ana Bošković and Maria-Elena Torres-Padilla.- Epigenetic regulation of pluripotency by polycomb group proteins by Achim Breiling.- PRC1-mediated gene silencing in pluripotent ES cells: function and evolution by Matthias Becker, Nancy Mah, Daniela Zdzieblo,  Xiaoli Li,  Arvind Mer, Miguel A. Andrade-Navarro, and Albrecht M. Müller.- The Biology and Genomic Localisation of Cytosine Modifications by Gordon R. McInroy, Neil M. Bell, Gabriella Ficz, Shankar Balasubramanian, Wolf Reik and Eun-Ang Raiber.- DNA methylation reprogramming in preimplantation development by Konstantin Lepikhov, Julia Arand, Sarah Fuchs, Jie Lan, Mark Wossidlo, and Jörn Walter.- Epigenetic reprogramming in cancer by Anders M. Lindroth, Yoon Jung Park, and Christoph Plass.- Establishing and Maintaining Pluripotency- An Epigenetic Perspective by Jing Liao and Alexander Meissner.- Glossary

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